| Autor: |
Cali, Ignazio, Espinosa, Juan Carlos, Nemani, Satish K., Marin-Moreno, Alba, Camacho, Manuel V., Rabail Aslam, Tetsuyuki Kitamoto, Appleby, Brian S., Torres, Juan Maria, Gambetti, Pierluigi |
| Rok vydání: |
2021 |
| DOI: |
10.6084/m9.figshare.14314067.v1 |
| Popis: |
Additional file 4 Fig. S4: Histopathology and PrP immunohistochemistry (IHC) in mice inoculated with sCJDVV2. i and iii: H.E. staining; ii and iv: PrP IHC. 1st row, i and ii: The cerebral cortex (CC), alveus (alv) and hippocampal CA1 regions were free of plaques and generated a negative PrP immunostaining. iii and iv: An aggregate (arrow) visible at H.E. (iii) was positively stained by an antibody (Ab) to PrP (iv). 2nd row, i and ii: Aggregates of plaques (i) affecting the lower brainstem immunoreacted with an Ab to PrP (ii); inset, i: higher magnification of congregate plaques. iii and iv: Plaques (arrowheads) distributed in a diagonal row in the upper brainstem; inset, iii and iv: a rounded plaque. Scale bar insets: 100 µm (1st row, iv) and 20 µm (2nd row, i); Ab: 3F4. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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