Development of magnetic dispersive micro-solid phase extraction based on magnetic agarose nanoparticles and deep eutectic solvents for the isolation and pre-concentration of three flavonoids in edible natural samples
| Autor: | Seyedeh Maedeh Majidi, Mohammad Reza Hadjmohammadi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Flavonoids
Chromatography Magnetic Phenomena Sepharose Solid Phase Extraction 010401 analytical chemistry Extraction (chemistry) Environmental pollution 02 engineering and technology Morin 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Analytical Chemistry Matrix (chemical analysis) chemistry.chemical_compound Adsorption chemistry Solvents Nanoparticles Solid phase extraction 0210 nano-technology Kaempferol Chromatography High Pressure Liquid Eutectic system |
| Zdroj: | Talanta. 222:121649 |
| ISSN: | 0039-9140 |
| DOI: | 10.1016/j.talanta.2020.121649 |
| Popis: | In the present study, an environmentally friendly magnetic dispersive micro-solid phase extraction was developed based on magnetic agarose nanoparticles and deep eutectic solvents for the isolation and pre-concentration of three flavonoids (morin, quercetin, and kaempferol) from dark tea, chocolate, vegetable, and fruit juice samples. In this method, deep eutectic solvents were synthesized from less toxic and low-cost substances under feasible conditions and used as eluents in the desorption process. These solvents can be considered as a green alternative to traditional organic reagents to increase the adsorption capacity and reduce the matrix interferences, dangerous waste generation and environmental pollution. A Plackett-Burman design was employed for screening the experimental variables. The effective variables were then optimized by Box-Behnken design (BBD). Under the optimial conditions, the presented method demonstrated wide linear ranges of 1–500 μg. L−1 for morin and quercetin, and 5–500 μg. L−1 for kaempferol with satisfactory recoveries above 91%. Limit of detections (LODs) and quantifications (LOQs) of flavonoids varied in 0.2–1.1 μg. L−1 and 0.66–3.63 μg. L−1, respectively. The precision of the proposed method was the range of 2.6–5.7%. |
| Databáze: | OpenAIRE |
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