Effectiveness of topical cycloplegics as anterior segment analgesics: systematic review and meta-analysis
| Autor: | Cindy M.L. Hutnik, Kevin Wong, Carter W. Lim, Monali S. Malvankar-Mehta |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Inflammation
medicine.medical_specialty Analgesics Mydriatics business.industry Context (language use) General Medicine Cyclopentolate law.invention Anterior chamber cells 03 medical and health sciences Ophthalmology 0302 clinical medicine Randomized controlled trial law Meta-analysis 030221 ophthalmology & optometry medicine Humans Statistical analysis In patient Intensive care medicine business Ocular inflammation medicine.drug |
| Zdroj: | Canadian journal of ophthalmology. Journal canadien d'ophtalmologie. 56(4) |
| ISSN: | 1715-3360 |
| Popis: | Objective Topical cycloplegic agents often are used in ophthalmology in the context of management of ocular inflammation. Preliminary searches of the literature provided little evidence to support their use in relieving pain or reducing inflammation. The goal of this study was to evaluate the current literature for any evidence regarding the effectiveness of cycloplegics for treatment of pain or inflammation in patients with anterior segment injury or inflammation through a systematic review and meta-analysis. Methods Using multiple keywords relating to cycloplegics and inflammatory and infectious eye conditions, a search was conducted on multiple scientific databases for relevant articles. A 2-level screening approach was used and articles that were relevant to the topic were included in the systematic review. Data from these articles, if applicable, were extracted for meta-analyses. Statistical assessments involved computation of I2statistics, Z-value, and χ2 statistics. Results We screened 5753 articles for relevance. Seven were included in the systematic review and 5 were included in the meta-analysis. There was considerable heterogeneity between the included studies. Statistical analysis revealed significant reductions in pain using homatropine and cyclopentolate after 2 days. Nonsignificant changes in the anterior chamber cells and flare were seen using cyclopentolate and atropine at different follow-up times. Conclusions Little published evidence exists in the literature to guide the use of cycloplegics on relieving pain and treating inflammation. Therefore, higher-quality randomized controlled trials with longer follow-up times are needed to fully understand the role that cycloplegics play in reducing pain in inflammatory conditions. |
| Databáze: | OpenAIRE |
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