Dehydroepiandrosterone is an anxiolytic in mice on the plus maze
| Autor: | Christine L. Melchior, R.F. Ritzmann |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Flumazenil
Male endocrine system Elevated plus maze medicine.medical_specialty Neuroactive steroid medicine.drug_class Clinical Biochemistry Dehydroepiandrosterone Motor Activity Toxicology Biochemistry Anxiolytic Behavioral Neuroscience chemistry.chemical_compound Mice Dehydroepiandrosterone sulfate Receptors GABA Internal medicine polycyclic compounds medicine Animals skin and connective tissue diseases Biological Psychiatry Pharmacology Benzodiazepine Diazepam Ethanol Chemistry Dehydroepiandrosterone Sulfate Mice Inbred C57BL Endocrinology Mechanism of action Anti-Anxiety Agents Pentylenetetrazole medicine.symptom human activities hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Pharmacology, biochemistry, and behavior. 47(3) |
| ISSN: | 0091-3057 |
| Popis: | Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are neurosteroids that have been shown to interact with the GABA system. The present study examined the effects of these compounds in mice on motor activity and behavior in the elevated plus maze. Doses of 0.5 mg/kg and above of DHEA reduced motor activity. This effect was blocked by diazepam, RO15-1788, pentylenetetrazole (PTZ), and ethanol. Both DHEA and DHEAS showed anxiolytic activity in the plus maze test, with DHEA being effective over a very wide range doses (5 μg/kg to 1.0 mg/kg). Both Ro15-1788 and PTZ blocked the anxiolytic effect of DHEA, there was no interaction with diazepam, and ethanol enhanced the anxiolytic effect of DHEA. At 1.0 mg/kg, DHEAS blocked the anxiolytic effect of ethanol. These results support the hypothesis that neurosteroids could be involved in the termination of a stress response. |
| Databáze: | OpenAIRE |
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