Emerging role of gasotransmitters in renal transplantation

Autor: Stephan J. L. Bakker, Pauline M. Snijder, van Harry Goor, E. van den Berg, Matthew Whiteman, Henri G. D. Leuvenink
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Nephrology
hydrogen sulfide
Apoptosis
ISCHEMIA-REPERFUSION INJURY
Pharmacology
BETA-SYNTHASE
Mice
chemistry.chemical_compound
Prevalence
Immunology and Allergy
Pharmacology (medical)
Carbon monoxide
Kidney transplantation
biology
Gasotransmitters
Incidence
cardiovascular health
Cytoprotection
Nitric oxide synthase
Biochemistry
Signal Transduction
medicine.medical_specialty
KIDNEY-TRANSPLANTATION
EXPERIMENTAL-MODEL
nephrology
SUPPLEMENTAL HYDROGEN-SULFIDE
ISCHEMIA/REPERFUSION INJURY
Nitric oxide
nitric oxide
Internal medicine
medicine
Animals
Humans
NITRIC-OXIDE SYNTHASE
CARBON-MONOXIDE
CYSTATHIONINE-GAMMA-LYASE
business.industry
medicine.disease
Kidney Transplantation
Transplantation
RAT-KIDNEY
Oxidative Stress
chemistry
biology.protein
Kidney Failure
Chronic
business
Kidney disease
transplantation
Zdroj: American Journal of Transplantation. 13(12):3067-3075
ISSN: 1600-6135
Popis: Once patients with kidney disease progress to end-stage renal failure, transplantation is the preferred option of treatment resulting in improved quality of life and reduced mortality compared to dialysis. Although 1-year survival has improved considerably, graft and patient survival in the long term have not been concurrent, and therefore new tools to improve long-term graft and patient survival are warranted. Over the past decades, the gasotransmitters nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) have emerged as potent cytoprotective mediators in various diseases. All three gasotransmitters are endogenously produced messenger molecules that possess vasodilatory, anti-apoptotic, anti-inflammatory and anti-oxidant properties by influencing an array of intracellular signaling processes. Although many regulatory functions of gasotransmitters have overlapping actions, differences have also been reported. In addition, crosstalk between NO, CO and H2S results in synergistic regulatory effects. Endogenous and exogenous manipulation of gasotransmitter levels modulates several processes involved in renal transplantation. This review focuses on mechanisms of gas-mediated cytoprotection and complex interactions between gasotransmitters in renal transplantation.
Databáze: OpenAIRE
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