Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors
| Autor: | Jessica Williams, Nicole D. Powell, Melanie A. McClain, Paul D. Robbins, Na Tosha N. Gatson, Teresa Hennon, Caroline C. Whitacre |
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| Rok vydání: | 2010 |
| Předmět: |
Encephalomyelitis
Autoimmune Experimental T cell T-Lymphocytes Immunology Blotting Western Enzyme-Linked Immunosorbent Assay medicine.disease_cause Exosomes Lymphocyte Activation Article Myelin oligodendrocyte glycoprotein Autoimmunity Myelin Mice Pregnancy Demyelinating disease Immunology and Allergy Medicine Animals biology business.industry Reverse Transcriptase Polymerase Chain Reaction Multiple sclerosis Experimental autoimmune encephalomyelitis medicine.disease Mice Inbred C57BL medicine.anatomical_structure Neurology Spinal Cord biology.protein Disease Progression Cytokines Female Neurology (clinical) business |
| Zdroj: | Journal of neuroimmunology. 230(1-2) |
| ISSN: | 1872-8421 |
| Popis: | Multiple sclerosis (MS) is a demyelinating disease of the CNS involving T cell targeting of myelin antigens. During pregnancy, women with MS experience decreased relapses followed by a post partum disease flare. Using murine experimental autoimmune encephalomyelitis, we recapitulate pregnancy findings in both relapsing and progressive models. Pregnant mice produced less TNF-α, IL-17 and exhibited reduced CNS pathology relative to non-pregnant controls. Microparticles, called exosomes, shed into the blood during pregnancy were isolated and found to significantly suppress T cell activation relative to those from non-pregnant controls. These results demonstrate the immunosuppressive potential of pregnancy and serum-derived pregnancy exosomes. |
| Databáze: | OpenAIRE |
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