A cytoplasmically transmitted, diet-dependent difference in response to the teratogenic effects of 6-aminonicotinamide
| Autor: | F. C. Fraser, D. R. Pollard, A. C. Verrusio |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
C57BL/6
Niacinamide medicine.medical_specialty Reciprocal cross Extrachromosomal Inheritance Biology Mice Pregnancy Internal medicine medicine Animals Inbreeding Maternal-Fetal Exchange Genetics Multidisciplinary Mouse strain digestive oral and skin physiology Abnormalities Drug-Induced Congenital cleft 6-Aminonicotinamide medicine.disease biology.organism_classification Diet Cleft Palate Endocrinology Hybridization Genetic Pregnancy Animal Female |
| Zdroj: | Science (New York, N.Y.). 160(3824) |
| ISSN: | 0036-8075 |
| Popis: | The frequency of congenital cleft palate produced by maternal treatment with 6-aminonicotinamide during pregnancy is lower in the C57BL/6J than in the A/J inbred mouse strain. In the C57BL/6J strain the frequency is lower when the mothers are maintained on Purina Lab Chow than when they are on Breeder Chow. A/J females do not show this effect of diet. There is a matroclinous reciprocal cross difference in frequency of induced cleft palate which persists in the back-cross when the F(1) mothers are maintained on Lab Chow but not on Breeder Chow. |
| Databáze: | OpenAIRE |
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