Evaluation of Safety and Antioxidant Activity of Yellow Tea (Camellia sinensis) Extract for Application in Food
| Autor: | Hanna Szaefer, Małgorzata Ewertowska, Anna Gramza-Michałowska, Jadwiga Jodynis-Liebert, Józef Korczak, Ewa Ignatowicz, Małgorzata Kujawska, Teresa Adamska |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Antioxidant medicine.medical_treatment Glutathione reductase Medicine (miscellaneous) Antioxidants Camellia sinensis Superoxide dismutase Lipid peroxidation Toxicology 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology medicine Animals Rats Wistar Glutathione Transferase chemistry.chemical_classification Glutathione Peroxidase Nutrition and Dietetics Traditional medicine biology Plant Extracts Superoxide Dismutase Glutathione peroxidase 04 agricultural and veterinary sciences Glutathione 040401 food science Rats 030104 developmental biology Glutathione Reductase chemistry Liver Toxicity biology.protein Female |
| Zdroj: | Journal of medicinal food. 19(3) |
| ISSN: | 1557-7600 |
| Popis: | The article presents an evaluation of the safety of yellow tea (Camellia sinensis) extract consumption and its antioxidant activity in an animal model. Wistar rats were exposed through diet to 2, 6, and 10 g yellow tea extract/kg feed for 90 days. No signs of toxicity and no differences in mean body weight gain in the treated and control rats were recorded throughout the experiment. No statistically significant differences in hematology findings and clinical chemistry parameters were observed between controls and treated groups. Microscopic examination of tissue sections revealed no pathology attributable to yellow tea extract intake. Lipid peroxidation level in the liver was slightly increased in medium-dose males and high-dose females and decreased in two female groups receiving 2 and 6 g/kg of the extract tested. Content of carbonyl groups in protein, as well as the basal level of DNA damage, was not changed. In a majority of rats, the activity of antioxidant enzymes was increased except superoxide dismutase in high-dose groups, glutathione peroxidase in high-dose females, glutathione reductase in low- and mid-dose groups, and glutathione S-transferase in mid-dose females and high-dose males. It could be concluded that rats tolerated well dietary treatment with yellow tea extract up to 0.8 g/kg b.w./day for 90 days. Results showed that yellow tea extract at the doses tested did not demonstrate adverse effects and improved the antioxidant status in the liver of rats. |
| Databáze: | OpenAIRE |
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