Family history is a strong risk factor for prevalent angle closure in a South Indian population
| Autor: | Emilie S. Chan, Krishnamurthy Palaniswamy, Srinivasan Kavitha, Pradeep Y. Ramulu, Nazlee Zebardast, Robert Wojciechowski, David S. Friedman, Rengaraj Venkatesh |
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| Rok vydání: | 2014 |
| Předmět: |
Proband
Adult Male medicine.medical_specialty endocrine system diseases Corneal Pachymetry Cross-sectional study education Gonioscopy Visual Acuity India Tonometry Ocular Age Distribution Asian People Risk Factors health services administration Internal medicine medicine Odds Ratio Prevalence Humans Sibling Family history Risk factor Intraocular Pressure Family Health medicine.diagnostic_test business.industry Siblings food and beverages Odds ratio Middle Aged humanities Confidence interval Surgery Ophthalmology Cross-Sectional Studies Phenotype Female Ocular Hypertension business Glaucoma Angle-Closure Glaucoma Open-Angle |
| Zdroj: | Ophthalmology. 121(11) |
| ISSN: | 1549-4713 |
| Popis: | To compare the prevalence of angle closure among siblings of patients with open angles (OAs), suspect angle closure (PACS), and either primary angle closure (PAC) or PAC glaucoma (PACG).Cross-sectional, clinical study.A total of 303 South Indian sibling pairs, including 81 OA probands, 143 PACS probands, and 79 PAC/PACG probands.Probands and siblings underwent a clinical examination, including gonioscopy by a masked grader, applanation tonometry, slit-lamp biomicroscopy, optic nerve evaluation, and A-scan ultrasonography. Probands and siblings were classified into 1 of 3 groups based on the phenotype of the more severely affected eye: OA, PACS, or PAC/PACG. Multivariable regression models were used to estimate the odds of prevalent angle closure in PACS or PAC/PACG siblings compared with OA siblings.Prevalence and relative prevalence of angle closure and PAC/PACG among OA, PACS, and PAC/PACG siblings.Mean sibling age was 49.7 ± 8.7 years, and 56.6% of siblings were females. Angle closure was more prevalent in both PACS siblings (35.0%) and PAC/PACG siblings (36.7%) compared with OA siblings (3.7%; P0.001). There was PAC/PACG present in 11.4% of PAC/PACG siblings compared with 4.9% of PACS siblings (P = 0.07) and 0% of OA siblings (P = 0.002). In multivariable models adjusting for sibling age and sex, the odds of angle closure was 13.6 times greater in angle closure (PACS or PAC/PACG) siblings compared with OA siblings (95% confidence interval [CI], 4.1-45.0; P0.001). Sibling angle-closure risk was also greater in female (odds ratio [OR], 2.3; 95% CI, 1.3-4.0; P = 0.005) and older siblings (OR, 1.5 per 10-year increment; 95% CI, 1.1-2.0; P = 0.02). Siblings of PAC/PACG probands had a 2.3-fold greater odds (95% CI, 0.8-6.5) of having PAC/PACG compared with siblings of PACS probands, although the association was not significant (P = 0.13).In the South Indian population screened, siblings of angle-closure patients had a1 in 3 risk of prevalent angle closure, whereas siblings of PAC/PACG patients had a10% risk of prevalent PAC/PACG. Screening siblings of angle-closure patients is likely to be of high yield in finding undetected angle closure. |
| Databáze: | OpenAIRE |
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