A retrospective analysis of high sensitivity cardiac troponin-T ranges in non-myocardial infarction emergency department visits

Autor: Sandeep Nathan, Xander M R van Wijk, Thomas Spiegel, Corey E. Tabit, Stephanie A. Besser, Nathan Kong, Louise Heelan, Rhys Chua
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
Renal function
Acute myocardial infarction
030204 cardiovascular system & hematology
Kidney
03 medical and health sciences
0302 clinical medicine
Sex Factors
Troponin T
Predictive Value of Tests
Internal medicine
Chronic kidney disease
Atrial Fibrillation
Diseases of the circulatory (Cardiovascular) system
Medicine
Humans
Myocardial infarction
Renal Insufficiency
Chronic
030304 developmental biology
Angiology
Aged
Retrospective Studies
Chicago
Heart Failure
0303 health sciences
Academic Medical Centers
business.industry
Research
Age Factors
Atrial fibrillation
Emergency department
Emergency Department
Middle Aged
medicine.disease
Cardiac surgery
Race Factors
RC666-701
Heart failure
Cardiac troponin
Female
Cardiology and Cardiovascular Medicine
business
Emergency Service
Hospital
Biomarkers
Kidney disease
Glomerular Filtration Rate
Zdroj: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-8 (2021)
ISSN: 1471-2261
Popis: Introduction Current evidence suggests that high sensitivity cardiac troponin-T (hs-cTnT) values differ based on sex, race, age, and kidney function. However, most studies examining the relationship of hs-cTnT and these individual factors are in healthy participants, leading to difficulty in interpreting hs-cTnT values in the Emergency Department (ED) setting. We seek to examine the relationship between hs-cTnT values and sex, race, age, and kidney function in a contemporary, urban academic setting. Methods ED visits from June 2018 through April 2019 with at least 1 hs-cTnT and no diagnosis of acute myocardial infarction (AMI) at an academic medical center in the south side of Chicago were retrospectively analyzed. Median hs-cTnT values were stratified by sex (male or female), race (African American or Caucasian), age, estimated glomerular filtration rate (eGFR), and stage of chronic kidney disease. Results 9679 encounters, representing 7989 distinct patients, were included for analysis (age 58 ± 18 years, 59% female, 85% black). Males had significantly higher median hs-cTnT values than females (16 [8–34] vs. 9 [6–22] ng/L, p p p p p Conclusions Analysis of hs-cTnT in non-AMI patients during ED encounters showed that males have higher values than females, African Americans have lower values than Caucasians, those with atrial fibrillation and heart failure have higher values than those without, and that older age and lower eGFR were associated with higher median values.
Databáze: OpenAIRE
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