Encephalitis and Death in Wild Mammals at a Rehabilitation Center after Infection with Highly Pathogenic Avian Influenza A(H5N8) Virus, United Kingdom
| Autor: | Ashley C. Banyard, Tobias Floyd, Rowena Hansen, Nicola S. Lewis, Ian H. Brown, Elliot Whittard, Steve Bexton, Michele Macrelli, Fabian Z. X. Lean, Edward Fullick, Alexander M. P. Byrne, Scott M. Reid, Benjamin C. Mollett, Alejandro Núñez, Vanessa Swinson, J. Paul Duff |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Epidemiology Seals Earless Highly pathogenic Captivity highly pathogenic Infectious and parasitic diseases RC109-216 Disease medicine.disease_cause Rehabilitation Centers Virus cetaceans respiratory infections systemic infection H5N8 medicine Animals viruses Influenza A Virus H5N8 Subtype first detection Wildlife rehabilitation Retrospective Studies biology business.industry Research Influenza A virus subtype H5N8 medicine.disease biology.organism_classification Virology Influenza A virus subtype H5N1 Encephalitis and Death in Wild Mammals at a Rehabilitation Center after Infection with Highly Pathogenic Avian Influenza A(H5N8) Virus United Kingdom United Kingdom zoonoses Infectious Diseases Influenza in Birds Medicine Encephalitis avian influenza terrestrial carnivores business |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 27, Iss 11, Pp 2856-2863 (2021) |
| Popis: | We report a disease and mortality event involving swans, seals, and a fox at a wildlife rehabilitation center in the United Kingdom during late 2020. Five swans had onset of highly pathogenic avian influenza virus infection while in captivity. Subsequently, 5 seals and a fox died (or were euthanized) after onset of clinical disease. Avian-origin influenza A virus subtype H5N8 was retrospectively determined as the cause of disease. Infection in the seals manifested as seizures, and immunohistochemical and molecular testing on postmortem samples detected a neurologic distribution of viral products. The fox died overnight after sudden onset of inappetence, and postmortem tissues revealed neurologic and respiratory distribution of viral products. Live virus was isolated from the swans, seals, and the fox, and a single genetic change was detected as a potential adaptive mutation in the mammalian-derived viral sequences. No human influenza-like illness was reported in the weeks after the event |
| Databáze: | OpenAIRE |
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