The bronchial response to mannitol is attenuated by a previous methacholine test: but not vice versa
| Autor: | Vibeke Backer, Celeste Porsbjerg, EJ Gade, Simon Francis Thomsen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Immunology Provocation test Bronchi Inhaled corticosteroids Bronchial Provocation Tests Interviews as Topic Young Adult Surveys and Questionnaires Administration Inhalation Humans Immunology and Allergy Medicine Mannitol Methacholine Chloride Lung function Aged Test order Dose-Response Relationship Drug business.industry Middle Aged Asthma Anesthesia Exhaled nitric oxide Female Methacholine Bronchial Hyperreactivity business Airway medicine.drug |
| Zdroj: | Clinical & Experimental Allergy. 39:966-971 |
| ISSN: | 1365-2222 0954-7894 |
| Popis: | AIM To examine the airway response to inhaled mannitol performed before or after a methacholine challenge test in a group of asthmatics with different levels of disease. METHODS A total of 48 asthmatics, 18-73 years of age, were included in the study. Two pairs of challenges were performed in a random order on two separate days > or =24 h apart: either with mannitol performed first on day one, followed > or =1 h by methacholine, and methacholine as the first on day two, followed > or =1 h by mannitol or vice versa. A questionnaire-based interview was performed and lung function, exhaled nitric oxide, skin prick test, and blood eosinophil count were measured. RESULTS A total of 44% of the asthmatics used inhaled corticosteroids and 48% were atopic. The airway response to mannitol was attenuated when mannitol was given after methacholine, compared with the response to mannitol when it was given first [log response dose ratio (RDR): 1.42 vs. 1.60 (P=0.004)], whereas the response to methacholine was unchanged in the opposite test order [log RDR: 0.81 vs. 0.96 (P=0.102)]. CONCLUSION Bronchial challenges with inhaled mannitol and methacholine may be performed on the same day but provocation with mannitol should be performed before methacholine. |
| Databáze: | OpenAIRE |
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