An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria

Autor: Stéphane Baeriswyl, Sacha Javor, Christian van Delden, Ivan Di Bonaventura, Giovanni Di Bonaventura, Thissa N. Siriwardena, Jean-Louis Reymond, Alice Capecchi, Arianna Pompilio, Xian Jin, Thilo Köhler, Runze He, Bee Ha Gan
Rok vydání: 2018
Předmět:
Acinetobacter baumannii
Secondary
Drug Resistance
Drug Evaluation
Preclinical
Peptide
Drug resistance
Bacillus subtilis/drug effects
medicine.disease_cause
01 natural sciences
Protein Structure
Secondary
chemistry.chemical_compound
Biofilms/drug effects
Protein structure
Drug Resistance
Multiple
Bacterial
540 Chemistry
Materials Chemistry
ddc:616
chemistry.chemical_classification
biology
Bicyclic molecule
Bacterial/drug effects
Metals and Alloys
Antimicrobial
Anti-Bacterial Agents
Surfaces
Coatings and Films
Electronic
Optical and Magnetic Materials
Pseudomonas aeruginosa
Multiple
Bacillus subtilis
Protein Structure
Microbial Sensitivity Tests
Molecular Dynamics Simulation
010402 general chemistry
Peptides
Cyclic
Pseudomonas aeruginosa/drug effects
Catalysis
Microbiology
Small Molecule Libraries
Thioether
Small Molecule Libraries/chemistry/pharmacology
medicine
Humans
Cell Membrane/drug effects
010405 organic chemistry
Cell Membrane
General Chemistry
biology.organism_classification
Antimicrobial Cationic Peptides/chemistry/pharmacology
0104 chemical sciences
Cyclic/chemistry/pharmacology
chemistry
Preclinical/methods
Biofilms
Ceramics and Composites
570 Life sciences
Drug Evaluation
Acinetobacter baumannii/drug effects
Anti-Bacterial Agents/chemistry/pharmacology
Peptides
Antimicrobial Cationic Peptides
Zdroj: Chemical Communications, Vol. 54, No 40 (2018) pp. 5130-5133
ISSN: 1364-548X
1359-7345
DOI: 10.1039/c8cc02412j
Popis: We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.
Databáze: OpenAIRE
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