Behavioural and neurodevelopmental impairment at school age following necrotising enterocolitis in the newborn period

Autor: Ida Voss Jensen, Rasmus Gregersen, Gorm Greisen, Sandra Meinich Juhl, Mathias Lühr Hansen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Pediatrics
medicine.medical_specialty
Adolescent
Birth weight
Denmark
Developmental Disabilities
Science
Child Behavior Disorders
Cerebral palsy
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Enterocolitis
Necrotizing
Risk Factors
030225 pediatrics
Surveys and Questionnaires
medicine
Humans
Child
Multidisciplinary
Child Behavior Disorders/epidemiology
business.industry
Cerebral Palsy
Confounding
Age Factors
Infant
Newborn
Gestational age
Retinopathy of prematurity
Neurodevelopmental Disorders/epidemiology
medicine.disease
Cerebral Palsy/epidemiology
Denmark/epidemiology
Enterocolitis
Necrotizing/complications
Neurodevelopmental Disorders
Child
Preschool
Necrotizing enterocolitis
Cohort
Head/pathology
Medicine
Female
business
Head
030217 neurology & neurosurgery
Cohort study
Developmental Disabilities/epidemiology
Follow-Up Studies
Zdroj: PLoS ONE, Vol 14, Iss 4, p e0215220 (2019)
Hansen, M L, Jensen, I V, Gregersen, R, Juhl, S M & Greisen, G 2019, ' Behavioural and neurodevelopmental impairment at school age following necrotising enterocolitis in the newborn period ', PLoS ONE, vol. 14, no. 4, e0215220 . https://doi.org/10.1371/journal.pone.0215220
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0215220
Popis: AIM: The aim of this study was to evaluate long-term behavioural and neurodevelopmental complications of neonatal necrotizing enterocolitis at school age.METHOD: This was a historic cohort study comparing all surviving children born in Denmark between 1st of January 2002 and 31st of December 2011 with a diagnosis of necrotizing enterocolitis to a group of children without necrotizing enterocolitis, but same gestational age, birth weight and year of birth. Outcomes were investigated through a parental questionnaire. The primary outcome was the Strength and Difficulties Questionnaire score and secondary outcomes were cerebral palsy and impaired head growth.RESULTS: Response rates were 50% (163 of 328) and 36% (237 of 652) among children with and without necrotizing enterocolitis, respectively. There was a higher rate of abnormal Strength and Difficulties score (23.9 versus 17.8%), moderate/severe cerebral palsy (3.1 versus 0.9%) and small head circumference for age (11.7 versus 7.2%) among children with necrotizing enterocolitis. However, these differences were all statistically insignificant and did not change significantly by adjustment for potential confounders.CONCLUSION: To our knowledge, this study includes the largest cohort of necrotizing enterocolitis children evaluated for possible long-term complications at school age. The increased risks of behavioural- and neurodevelopmental impairments were statistically insignificant, moderate in magnitude and may be of little clinical importance for management in the neonatal period or when planning follow-up.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje