Poor nutrition and sarcopenia are related to systemic inflammatory response in patients with rectal cancer undergoing preoperative chemoradiotherapy
| Autor: | Yuichiro Yokoyama, Yuzo Nagai, Shinya Abe, Kazushige Kawai, Hirofumi Sonoda, Koji Murono, Shigenobu Emoto, Soichiro Ishihara, Tsuyoshi Ozawa, Kazuhito Sasaki, Junko Kishikawa, Hiroaki Nozawa, Hiroyuki Anzai |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Sarcopenia Colorectal cancer Gastroenterology Metastasis Internal medicine medicine Humans Clinical significance Radical surgery Neoplasm Staging Retrospective Studies business.industry Rectal Neoplasms Hazard ratio Malnutrition Chemoradiotherapy Hepatology medicine.disease Prognosis Neoadjuvant Therapy Systemic Inflammatory Response Syndrome business |
| Zdroj: | International journal of colorectal disease. 37(1) |
| ISSN: | 1432-1262 |
| Popis: | Preoperative chemoradiotherapy (CRT) is the standard therapy for locally advanced rectal cancer (LARC). However, the changes that the patient’s physical status during CRT, such as host systemic inflammatory response, nutritional status, and muscle depletion, are still unclear. We evaluated the clinical significance of malnutrition and sarcopenia for patients with LARC undergoing CRT. Patients with LARC treated with CRT following radical surgery at our institution between 2006 and 2016 (N = 225) were retrospectively analyzed. A new prognostic score (PNSI) was devised based on the prognostic nutritional index (PNI) and the psoas muscle mass index (PMI): patients with malnutrition/sarcopenia were scored 2; patients with one and neither abnormality were scored 1 and 0, respectively. Neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and platelet/lymphocyte ratio increased, whereas PNI and PMI decreased after CRT. There were 130, 73, and 22 patients in the PNSI 0, 1, and 2 groups, respectively. Patients with higher PNSI had higher residual tumor size (p = 0.003), yT stage (p = 0.007), ypStage (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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