High-frequency irreverisble electroporation for cardiac ablation using an asymmetrical waveform
| Autor: | Albert H. Westra, Fred H.M. Wittkampf, Kars Neven, Maurits K. Konings, René van Es, Vincent J. van Driel, Pieter A. Doevendans, Bastiaan C. du Pré, Harry van Wessel |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Ablation Techniques
lcsh:Medical technology Materials science Swine medicine.medical_treatment 0206 medical engineering Biomedical Engineering 02 engineering and technology law.invention Biomaterials law medicine Animals Waveform Radiology Nuclear Medicine and imaging Animal study Electrolysis Radiological and Ultrasound Technology Research Direct current fungi Electric Conductivity Arrhythmias Cardiac General Medicine Irreversible electroporation Cardiac Ablation Ablation Myocardial Contraction 020601 biomedical engineering Electroporation lcsh:R855-855.5 Alternating current Biomedical engineering |
| Zdroj: | BioMedical Engineering Online, 18. BioMed Central BioMedical Engineering BioMedical Engineering OnLine, Vol 18, Iss 1, Pp 1-13 (2019) |
| ISSN: | 1475-925X |
| Popis: | Background Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general anesthesia due to severe muscle contractions and the formation of bubbles containing gaseous products from electrolysis. The use of high-frequency alternating current (HF-IRE) is expected to solve both problems, because HF-IRE produces little to no muscle spasms and does not cause electrolysis. Methods In the present study, we introduce a novel asymmetric, high-frequency (aHF) waveform for HF-IRE and present the results of a first, small, animal study to test its efficacy. Results The data of the experiments suggest that the aHF waveform creates significantly deeper lesions than a symmetric HF waveform of the same energy and frequency (p = 0.003). Conclusion We therefore conclude that the use of the aHF enhances the feasibility of the HF-IRE method. |
| Databáze: | OpenAIRE |
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