Evidence for the Occurrence of Human Erythrocyte Membrane Sialoglycoproteins in Human Kidney Endothelial Cells
| Autor: | J. Harvey, B.A. Bradley, S.F. Parsons, D.J. Anstee |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Endothelium
medicine.drug_class Sialoglycoproteins Kidney urologic and male genital diseases Monoclonal antibody Epitope Immunoenzyme Techniques medicine Humans Glycophorin Glycophorins biology Antibodies Monoclonal Hematology General Medicine Molecular biology Red blood cell medicine.anatomical_structure Immunology cardiovascular system biology.protein MNSs Blood-Group System Antibody |
| Zdroj: | Vox Sanguinis. 55:104-108 |
| ISSN: | 1423-0410 0042-9007 |
| Popis: | Several mouse monoclonal antibodies recognising different epitopes on human erythrocyte sialoglycoproteins alpha and beta (syn: glycophorins A and C, respectively) react with human renal endothelium. Those monoclonal anti-blood group M and anti-blood group N antibodies which recognised the M/N epitopes on sialidase-treated human erythrocytes also reacted with human renal endothelium whilst those which recognise the M/N epitopes on native, but not on sialidase-treated human erythrocytes were not reactive with human renal endothelium. These results provide evidence for the occurrence of alpha and beta molecules in renal endothelium and suggest that alpha in renal endothelium is incompletely sialylated. |
| Databáze: | OpenAIRE |
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