Sending a message: extracellular vesicles of pathogenic protozoan parasites
| Autor: | John M. Harrington, Anthony J. Szempruch, Lauren Dennison, Rudo Kieft, Stephen L. Hajduk |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cell signaling Plasmodium Trypanosoma Virulence Factors 030106 microbiology Virulence Cell Communication medicine.disease_cause Microbiology Host-Parasite Interactions 03 medical and health sciences Extracellular Vesicles Immune system parasitic diseases medicine Trichomonas vaginalis Animals Humans Parasites Leishmania General Immunology and Microbiology biology Biological Transport biology.organism_classification Obligate parasite Cell biology 030104 developmental biology Infectious Diseases |
| Zdroj: | Nature reviews. Microbiology. 14(11) |
| ISSN: | 1740-1534 |
| Popis: | Parasitic unicellular eukaryotes use extracellular vesicles (EVs) as vehicles for intercellular communication and host manipulation. By using various mechanisms to generate EVs and by transferring a wide range of molecules through EVs, pathogenic protozoans are able to establish infective niches, modulate the immune system of the host and cause disease. In addition to effects on the host, EVs are able to transfer virulence factors, drug-resistance genes and differentiation factors between parasites. In this Progress article, we explore recent insights into the biology of EVs from human infectious protozoan parasites, including Trichomonas vaginalis, Plasmodium spp. and kinetoplastids, such as Trypanosoma spp. and Leishmania spp. |
| Databáze: | OpenAIRE |
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