Anti-proliferative and ROS-inhibitory activities reveal the anticancer potential of Caulerpa species
| Autor: | Avinash Mishra, Sonam Yadav, Bhakti Tanna |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Flavonoid HeLa 03 medical and health sciences Caulerpa racemosa 0302 clinical medicine Nutraceutical Functional food Neoplasms Genetics medicine Caulerpa Humans Molecular Biology Cell Proliferation EC50 chemistry.chemical_classification biology Traditional medicine General Medicine biology.organism_classification Antineoplastic Agents Phytogenic 030104 developmental biology chemistry 030220 oncology & carcinogenesis Reactive Oxygen Species HeLa Cells |
| Zdroj: | Molecular Biology Reports. 47:7403-7411 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | Seaweeds are considered a promising functional food and safe for human consumption as they have significant health benefits. Five abundant tropical seaweeds, Caulerpa racemosa var. macrophysa, Caulerpa scalpelliformis, Grateloupia indica, Sargassum linearifolium, and Spatoglossum asperum rich in metabolites, phenolic, and flavonoid compounds, were analyzed for the anti-proliferative and ROS inhibitory activities including transcript expression of cancer-linked key genes and apoptosis. C. racemosa var. macrophysa showed the maximum effective activities with a lower dose of extract, about 130 ± 30 and 23 ± 1 μg ml−1 EC50 dose for HeLa and Huh-7, respectively, followed by C. scalpelliformis, showing EC50 dose about 200 ± 10 and 140 ± 30 μg ml−1, respectively. Similarly, about 56% and 54% ROS inhibition were determined with Caulerpa spp. for HeLa and Huh-7 cells, respectively. Results indicated that tropical green seaweed Caulerpa spp. (C. racemosa var. macrophysa and C. scalpelliformis) have substantial potential of ROS inhibition. Further, it was observed that different cancer-linked marker proteins encoding genes were deferentially expressed with seaweed extracts in different cell lines. Overall, it is concluded that Caulerpa spp. are rich in antioxidant and anti-proliferative activities. Caulerpa spp. have potential to be explored further for cancer preventive properties or functional food or nutraceuticals applications. |
| Databáze: | OpenAIRE |
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