Flavusides A and B, Antibacterial Cerebrosides from the Marine-Derived Fungus Aspergillus flavus
| Autor: | Keumja Yun, Jung Sook Kang, Gun-Do Kim, Hong Dae Choi, Jongki Hong, Alain Simplice Leutou, Louis P. Sandjo, Byeng Wha Son, Guohua Yang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Aquatic Organisms Staphylococcus aureus Magnetic Resonance Spectroscopy Molecular Conformation Aspergillus flavus Microbial Sensitivity Tests Fungus medicine.disease_cause Glycosphingolipids Microbiology chemistry.chemical_compound Minimum inhibitory concentration Cerebrosides Tandem Mass Spectrometry Drug Resistance Bacterial Drug Discovery medicine Chromatography biology Strain (chemistry) Chemistry General Chemistry General Medicine biology.organism_classification Cerebroside Anti-Bacterial Agents Antibacterial activity Kojic acid |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 59:1174-1177 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.59.1174 |
| Popis: | Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 μg/ml for S. aureus and 31.2 μg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 μg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 μg/ml for multidrug-resistant S. aureus. |
| Databáze: | OpenAIRE |
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