Fatty acid intake and breast cancer in the Spanish multicase-control study on cancer (MCC-Spain)
| Autor: | Jesús Castilla, Marcela Guevara, Beatriz Pérez-Gómez, Inés Gómez-Acebo, Manolis Kogevinas, Marian Diaz-Santos, Paz Rodríguez-Cundín, Camilo Palazuelos, Guillermo Fernández-Tardón, Pilar Amiano, Javier Llorca, Jéssica Alonso-Molero, Nuria Aragonés, Ana López-Gonzalez, Vicente Martín, Ana Molina-Barceló, Rafael Marcos-Gragera, Madalen Oribe, Esther Gracia-Lavedan, Trinidad Dierssen-Sotos, Gemma Castaño-Vinyals, Marina Pollán |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Saturated fat Population Medicine (miscellaneous) 030209 endocrinology & metabolism Breast Neoplasms Gastroenterology 03 medical and health sciences Polyunsaturated fat 0302 clinical medicine Breast cancer Internal medicine medicine Humans Total fat education Dietary fat Monounsaturated fat chemistry.chemical_classification education.field_of_study 030109 nutrition & dietetics Nutrition and Dietetics business.industry Fatty Acids Fatty acid intake Cancer Fatty acid MCC-Spain Middle Aged medicine.disease Dietary Fats chemistry Spain Case-Control Studies Female business |
| Zdroj: | EUROPEAN JOURNAL OF NUTRITION r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) |
| ISSN: | 1436-6207 |
| Popis: | Purpose To evaluate the association between dietary fat and fat subtype and breast cancer development. Methods We conducted a case-control study with 1181 cases of incident breast cancer, diagnosed between 2007 and 2012, and 1682 population controls frequency matched (by age, sex, and region) from the Spanish multicenter case-control study MCC-Spain. Results We found a significant protective effect in premenopausal women of total fat intake [OR 0.51 95% CI (0.31-0.86) highest versus lowest tertile], but no effect was observed in menopausal women [OR 1.15 95% CI (0.83-1.60)]. Analyzing by type of fat, this protective effect persisted only for the monounsaturated fatty acids [OR 0.51 95% CI (0.32-0.82)]. In contrast, other fatty acids did not have a significant effect. In addition, a protection against risk of breast cancer was found when polyunsaturated fats were "substituted" by monounsaturated, maintaining the same total fat intake [OR 0.68 95% CI (0.47-0.99)]. Finally, analyzing by breast cancer subtype, we found no effect, except in premenopausal women where intake of moderate [OR 0.52 95% CI (0.33-0.82)] and high monounsaturated fatty acids [OR 0.47 95% CI (0.27-0.82)] maintains a protective effect against ER/PR + tumors. In contrast, in menopausal women, a high intake of monounsaturated fatty acids was associated with higher risk of HER2 + tumors [OR 2.00 95% CI (0.97-4.13)]. Conclusion Our study shows a differential effect of monounsaturated fatty acids according to menopausal status and breast cancer subtype. |
| Databáze: | OpenAIRE |
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