The functional role of metabotropic glutamate receptors in epileptiform activity induced by 4-aminopyridine in the rat amygdala slice
| Autor: | Viktor L. Arvanov, N. Bradley Keele, Keith H. Holmes, Patricia Shinnick-Gallagher |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Glycine Receptors Metabotropic Glutamate Benzoates Amygdala Rats Sprague-Dawley Bursting Convulsion medicine Animals Ictal 4-Aminopyridine Molecular Biology Epilepsy Chemistry General Neuroscience Glutamate receptor Rats nervous system diseases Electrophysiology medicine.anatomical_structure Metabotropic receptor nervous system Metabotropic glutamate receptor Neurology (clinical) medicine.symptom Excitatory Amino Acid Antagonists Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 669:140-144 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(94)01243-b |
| Popis: | The metabotropic glutamate receptor (mGluR) antagonist, (RS)-α-methyl-4-carboxyphenylglycine (MCPG; 500 μM), was tested on intracellularly recorded epileptiform activity induced by 4-aminopyridine (4-AP) in amygdala neurons. Superfusing 4-AP (1 mM) produced interictal spiking followed by ictal bursting. MCPG prevented the progressive transition from interictal spiking to ictal bursting but affected neither induction of interictal spiking nor maintenance of ongoing ictal bursting. These data suggest that mGluRs may be involved in the induction of ictal seizure events. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|