Operation and Chemotherapy: Prognostic Factors for Lung Cancer With One Synchronous Metastasis
| Autor: | Denis Moro-Sibilot, Anne-Claire Toffart, Laurent Selek, Isabelle Dumas, Pierre-Yves Brichon, Julie Villa, Matteo Giaj Levra, Augustin Pirvu, Michael Duruisseaux, P. Guillem, L. Ferrer |
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| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Male medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Antineoplastic Agents 030204 cardiovascular system & hematology Metastasis Neoplasms Multiple Primary 03 medical and health sciences Pneumonectomy 0302 clinical medicine Interquartile range Internal medicine Carcinoma Non-Small-Cell Lung Carcinoma medicine Humans Stage (cooking) Lung cancer Survival rate Aged Neoplasm Staging Retrospective Studies Chemotherapy business.industry Middle Aged medicine.disease Combined Modality Therapy Survival Rate 030220 oncology & carcinogenesis Surgery Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | The Annals of thoracic surgery. 105(3) |
| ISSN: | 1552-6259 |
| Popis: | Background Stage IV non-small cell lung cancer (NSCLC) is considered incurable; however, some patients with only few metastases may benefit from treatment with a curative intent. We aimed to identify the prognostic factors for stage IV NSCLC with synchronous solitary M1. Methods A database constructed from our weekly multidisciplinary thoracic oncology meetings was retrospectively screened from 1993 to 2012. Consecutive patients with NSCLC stages I to IV were included. Results Of the 6,760 patients found, 4,832 patients were studied. Among the 1,592 patients (33%) with stage IV NSCLC, 109 (7%) had a synchronous solitary M1. Metastasis involved the brain in 64% of patients. Median overall survival was significantly longer in synchronous solitary M1 than in other stage IV (18.9 months, interquartile range [IQR]: 9.9 to 34.6 months versus 6.1 months, IQR: 2.3 to 13.7 months], respectively, p Conclusions Synchronous solitary M1 treated with chemotherapy and operation at both sites resulted in better survival. Survival of NSCLC with synchronous solitary M1 was more similar to stage III than other stage IV NSCLCs. The eighth TNM classification takes this into account by distinguishing between stages M1b and M1c. |
| Databáze: | OpenAIRE |
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