Prevalence of unknown thyroid disorders in a Sardinian cohort
| Autor: | Lenuta Balaci, Francesco Loi, Alessandro P Delitala, Liana Anna Pina Ferreli, Francesco Cucca, David Schlessinger, Maria Grazia Pilia, Nicolò Curreli |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Goiter endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Thyroid Gland Iodide Peroxidase Thyroglobulin Article Age Distribution Endocrinology Thyroid peroxidase Internal medicine medicine Humans Aged Subclinical infection Aged 80 and over biology business.industry Thyroid General Medicine Middle Aged medicine.disease Thyroid Diseases Iodine deficiency Anti-thyroid autoantibodies Thyroxine Cross-Sectional Studies medicine.anatomical_structure biology.protein Thyroid function business |
| Zdroj: | European Journal of Endocrinology. 171:143-149 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje-14-0182 |
| Popis: | ObjectiveTo assess thyroid function, the presence of thyroid antibodies, as well as the presence of goiter and/or nodules in subjects without a prior diagnosis of thyroid disorders, in a region with mild to moderate iodine deficiency.Design and methodsThis cross-sectional study is based on data obtained from first and third visits of participants in the Sardinian survey. We performed two different analyses. In one, we assessed the prevalence of unknown thyroid dysfunctions among 6252 subjects who had a medical examination and blood collection for assays of thyrotropin, free thyroxine, and antibodies against thyroperoxidase (AbTPO) and against thyroglobulin (AbTG). In a second analysis, we evaluated the frequency of undiagnosed goiter and nodules among 3377 subjects who had a thyroid ultrasound scan. Subjects were excluded if they had a previous history of thyroid disorders or presence of goiter and/or nodules, or thyroid surgery, or if they were taking drugs that could impair thyroid function.ResultsWe found a low prevalence of overt thyroid dysfunction (hyperthyroidism 0.4% and hypothyroidism 0.7%). The rates of subclinical hypothyroidism and hyperthyroidism were 4.7 and 2.4% respectively. Almost 16% of participants were positive for at least one antibody and 5.2% for both AbTG and AbTPO. Nodules were detected in 17.4% of subjects and the prevalence of goiter was 22.1%.ConclusionsUndiagnosed biochemical thyroid dysfunctions, unknown nodules, and goiter were common in subjects living in a mild to moderate iodine-deficient area. In this community, thyroid disorders often go undetected and screening could be reasonable in subjects at a higher risk. |
| Databáze: | OpenAIRE |
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