Racial Differences in HLA Class II Associations with Hepatitis C Virus Outcomes
| Autor: | Kenrad E. Nelson, Darlene Marti, Chloe L. Thio, Jacquie Astemborski, David Vlahov, Stephen J. O'Brien, Peter Karacki, Margaret W. Hilgartner, Mary Carrington, David L. Thomas, James J. Goedert |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Cellular immunity Hepacivirus Hepatitis C virus Black People Human leukocyte antigen medicine.disease_cause White People Cohort Studies HLA-DQ Antigens medicine HLA-DQ beta-Chains Humans Immunology and Allergy Alleles HLA-DQB1 biology Histocompatibility Antigens Class II HLA-DR Antigens Odds ratio biology.organism_classification Hepatitis C Virology Infectious Diseases Haplotypes Immunology Cohort Disease Progression Female Viral disease HLA-DRB1 Chains |
| Zdroj: | The Journal of Infectious Diseases. 184:16-21 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/321005 |
| Popis: | A broad, vigorous CD4 T cell response, mediated by class II human leukocyte antigens (HLAs), favors hepatitis C virus (HCV) clearance. HLA-DQB1*0301 has been associated with viral clearance in an ethnically homogeneous cohort. To validate this association and to identify other class II associations in an ethnically varied cohort, molecular class II HLA typing was performed on 200 HCV clearance and 374 matched persistently infected subjects. HLA-DQB1*0301 was weakly associated with viral clearance in combined ethnic groups (odds ratio [OR], 0.72; 95% confidence interval [CI], 0.53-0.97) but was stronger in black subjects. In white subjects, viral clearance was associated with DRB1*0101 (OR, 0.32; 95% CI, 0.17-0.60) and its DQB1*0501 haplotype, whereas viral persistence was associated with DRB1*0301 (OR, 2.36; 95% CI, 1.23-4.52) and its DQB1*0201 haplotype. These results support a role for class II alleles in the immune response to HCV and underscore the importance of studying genetic associations in an ethnically diverse cohort. |
| Databáze: | OpenAIRE |
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