Antibodies as Biosensors’ Key Components: State-of-the-Art in Russia 2020–2021
| Autor: | Fedor Brovko, A. P. Karatovskaya, A. O. Shepelyakovskaya, N. N. Rudenko, K. K. Fursova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Computer science
multiplex test systems High selectivity immunosensors recombinant antibodies Review Biosensing Techniques TP1-1185 Biochemistry Antibodies Analytical Chemistry Russia Key point Nanosensor medicine Nanotechnology Electrical and Electronic Engineering Instrumentation Immunoassay medicine.diagnostic_test Chemical technology lateral flow immunoassay Atomic and Molecular Physics and Optics Highly sensitive analytical microchips protein scaffolds Key (cryptography) Biochemical engineering State (computer science) monoclonal antibodies Biosensor nanosensors |
| Zdroj: | Sensors, Vol 21, Iss 7614, p 7614 (2021) Sensors (Basel, Switzerland) |
| ISSN: | 1424-8220 |
| Popis: | The recognition of biomolecules is crucial in key areas such as the timely diagnosis of somatic and infectious diseases, food quality control, and environmental monitoring. This determines the need to develop highly sensitive display devices based on the achievements of modern science and technology, characterized by high selectivity, high speed, low cost, availability, and small size. Such requirements are met by biosensor systems—devices for reagent-free analysis of compounds that consist of a biologically sensitive element (receptor), a transducer, and a working solution. The diversity of biological material and methods for its immobilization on the surface or in the volume of the transducer and the use of nanotechnologies have led to the appearance of an avalanche-like number of different biosensors, which, depending on the type of biologically sensitive element, can be divided into three groups: enzyme, affinity, and cellular/tissue. Affinity biosensors are one of the rapidly developing areas in immunoassay, where the key point is to register the formation of an antigen–antibody complex. This review analyzes the latest work by Russian researchers concerning the production of molecules used in various immunoassay formats as well as new fundamental scientific data obtained as a result of their use. |
| Databáze: | OpenAIRE |
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