Combining Materials Obtained by 3D-Printing and Electrospinning from Commercial Polylactide Filament to Produce Biocompatible Composites

Autor:	Francisca Pavicic, Judit G. Lisoni, Verena Cárdenas, Ariel Nenen, Pamela Ehrenfeld, Mario E. Flores, Victor Pino, Pablo Romero-Araya, Ignacio Moreno-Villoslada, Guillaume Sérandour
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Materials science Polymers and Plastics Biocompatibility Simulated body fluid Composite number technology industry and agriculture Organic chemistry General Chemistry Polyethylene glycol Dynamic mechanical analysis PLA 3D-printing Biodegradable polymer Electrospinning Article chemistry.chemical_compound QD241-441 PLA electrospun fibers chemistry Tissue engineering biocompatible composites Composite material biomimetic composites
Zdroj:	Polymers Volume 13 Issue 21 Polymers, Vol 13, Iss 3806, p 3806 (2021)
ISSN:	2073-4360
Popis:	The design of scaffolds to reach similar three-dimensional structures mimicking the natural and fibrous environment of some cells is a challenge for tissue engineering, and 3D-printing and electrospinning highlights from other techniques in the production of scaffolds. The former is a well-known additive manufacturing technique devoted to the production of custom-made structures with mechanical properties similar to tissues and bones found in the human body, but lacks the resolution to produce small and interconnected structures. The latter is a well-studied technique to produce materials possessing a fibrillar structure, having the advantage of producing materials with tuned composition compared with a 3D-print. Taking the advantage that commercial 3D-printers work with polylactide (PLA) based filaments, a biocompatible and biodegradable polymer, in this work we produce PLA-based composites by blending materials obtained by 3D-printing and electrospinning. Porous PLA fibers have been obtained by the electrospinning of recovered PLA from 3D-printer filaments, tuning the mechanical properties by blending PLA with small amounts of polyethylene glycol and hydroxyapatite. A composite has been obtained by blending two layers of 3D-printed pieces with a central mat of PLA fibers. The composite presented a reduced storage modulus as compared with a single 3D-print piece and possessing similar mechanical properties to bone tissues. Furthermore, the biocompatibility of the composites is assessed by a simulated body fluid assay and by culturing composites with 3T3 fibroblasts. We observed that all these composites induce the growing and attaching of fibroblast over the surface of a 3D-printed layer and in the fibrous layer, showing the potential of commercial 3D-printers and filaments to produce scaffolds to be used in bone tissue engineering.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fe1ff20a10773ab1545998ac1f3b6f http://europepmc.org/articles/PMC8588263 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.