Prognostic Value of Systemic Immune-Inflammation Index for Major Adverse Cardiac Events and Mortality in Severe Aortic Stenosis Patients after TAVI
| Autor: | Halil İbrahim Biter, Aydin Rodi Tosu, Muhsin Kalyoncuoğlu, Tufan Çınar, Murat Selçuk, Sinem Cakal, Erdal Belen, Mehmet Mustafa Can |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) Transcatheter aortic Severity of Illness Index Article Transcatheter Aortic Valve Replacement TAVI R5-920 Risk Factors Internal medicine medicine Humans cardiovascular diseases Stroke major adverse cardiac events Retrospective Studies Proportional hazards model business.industry Area under the curve General Medicine Aortic Valve Stenosis medicine.disease Prognosis Predictive value mortality SII Stenosis Treatment Outcome inflammation Aortic Valve Cardiology business Immune inflammation |
| Zdroj: | Medicina Medicina, Vol 57, Iss 588, p 588 (2021) Volume 57 Issue 6 |
| ISSN: | 1648-9144 1010-660X |
| Popis: | Background and objectives: In this study, we aimed to evaluate whether the systemic immune-inflammation index (SII) has a prognostic value for major adverse cardiac events (MACEs), including stroke, re-hospitalization, and short-term all-cause mortality at 6 months, in aortic stenosis (AS) patients who underwent transcatheter aortic valve implantation (TAVI). Materials and Methods: A total of 120 patients who underwent TAVI due to severe AS were retrospectively included in our study. The main outcome of the study was MACEs and short-term all-cause mortality at 6 months. Results: The SII was found to be higher in TAVI patients who developed MACEs than in those who did not develop them. Multivariate Cox regression analysis revealed that the SII (HR: 1.002, 95%CI: 1.001–1.003, p < 0.01) was an independent predictor of MACEs in AS patients after TAVI. The optimal value of the SII for MACEs in AS patients following TAVI was > 1.056 with 94% sensitivity and 96% specificity (AUC (the area under the curve): 0.960, p < 0.01). We noted that the AUC value of SII in predicting MACEs was significantly higher than the AUC value of the C-reactive protein (AUC: 0.960 vs. AUC: 0.714, respectively). Conclusions: This is the first study to show that high pre-procedural SII may have a predictive value for MACEs and short-term mortality in AS patients undergoing TAVI. |
| Databáze: | OpenAIRE |
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