Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease
| Autor: | Shoichiro Ohta, Ulf Hammar, Cilla Söderhäll, Barbro Dahlén, Kenji Izuhara, Sven-Erik Dahlén, Maciej Kupczyk, Juha Kere, Anna James, Elisabeth H. Bel, Rolf G. Boot, Junya Ono, Lovisa E. Reinius, Marri Verhoek, Anna Gomes |
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| Přispěvatelé: | Other departments, AII - Amsterdam institute for Infection and Immunity, Pulmonology |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine AIRWAY INFLAMMATION Disease Critical Care and Intensive Care Medicine Severity of Illness Index Pulmonary Disease Chronic Obstructive chitotriosidase 0302 clinical medicine Lectins Multicenter Studies as Topic Longitudinal Studies Young adult Chitinase-3-Like Protein 1 COPD CHITINASE-LIKE PROTEIN Smoking GENETIC-VARIATION Middle Aged Europe LUNG-FUNCTION Hexosaminidases ATOPIC ASTHMA Disease Progression Regression Analysis Female Steroids Adult Pulmonary and Respiratory Medicine medicine.medical_specialty YKL-40 Adolescent MAMMALIAN CHITINASE Adipokine CHI3L1 chronic obstructive pulmonary disease Young Adult 03 medical and health sciences Adipokines Internal medicine 3-LIKE 1 Severity of illness medicine Humans ALLERGEN CHALLENGE MATRIX PROTEIN Aged Asthma Polymorphism Genetic business.industry GLYCOSYL HYDROLASES asthma medicine.disease respiratory tract diseases 030104 developmental biology 030228 respiratory system Immunology business Biomarkers |
| Zdroj: | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE American Journal of Respiratory and Critical Care Medicine, 193(2), 131-142. AMER THORACIC SOC American journal of respiratory and critical care medicine, 193(2), 131-142. American Thoracic Society AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193(2), 131-142 |
| ISSN: | 1535-4970 1073-449X |
| Popis: | Rationale: Serum chitinases may be novel biomarkers of airway inflammation and remodeling, but less is known about factors regulating their levels. Objectives: To examine serum chitotriosidase activity and YKL-40 levels in patients with asthma and chronic obstructive pulmonary disease (COPD) and evaluate clinically relevant factors that may affect chitinase levels, including genetic variability, corticosteroid treatment, disease exacerbations, and allergen exposure. Methods: Serum chitotriosidase (CHIT1) activity and YKL-40 (CHI3L1) levels, as well as the CHIT1 rs3831317 and CHI3L1 rs4950928 genotypes, were examined in subsets of patients with mild to moderate asthma (n = 76), severe asthma (n = 93), and COPD (n = 64) taking part in the European multicenter BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) study. Blood was obtained at baseline, before and after a 2-week oral steroid intervention, up to six times during a 1-year period, and during exacerbations. Baseline chitinase levels were also measured in 72 healthy control subjects. The effect of allergen inhalation on blood and sputum YKL-40 levels was measured in two separate groups of patients with mild atopic asthma; one group underwent repeated low-dose allergen challenge (n = 15), and the other underwent high-dose allergen challenge (n = 16). Measurements and Main Results: Serum chitotriosidase and YKL-40 were significantly elevated in patients with asthma and those with COPD compared with healthy control subjects. Genotype and age strongly affected both YKL-40 and chitotriosidase activity, but associations with disease remained following adjustment for these factors. Correlations were observed with lung function but not with other biomarkers, including exhaled nitric oxide, blood eosinophils, periostin, and IgE. Generally, acute exacerbations, allergen-induced airway obstruction, and corticosteroid treatment did not affect circulating chitinase levels. Conclusions: YKL-40 and chitotriosidase are increased in asthma and more so in COPD. The data in the present study support these substances as being relatively steroid-insensitive, non T-helper cell type 2 type biomarkers distinctly related to chronic inflammatory disease processes. |
| Databáze: | OpenAIRE |
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