Cross-species functional analyses reveal shared and separate roles for Sox11 in frog primary neurogenesis and mouse cortical neuronal differentiation
| Autor: | Maria J. Donoghue, Garrett A. Lee, Jing Jin, Chao Chen, Elena M. Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Nervous system QH301-705.5 Science Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Subplate medicine Biology (General) Transcription factor Neurogenesis Neural tube Anatomy Corticogenesis 030104 developmental biology medicine.anatomical_structure Neural development Neuronal differentiation Sox transcription factor General Agricultural and Biological Sciences Neural plate Neuroscience Research Article |
| Zdroj: | Biology Open, Vol 5, Iss 4, Pp 409-417 (2016) Biology Open |
| ISSN: | 2046-6390 |
| Popis: | A well-functioning brain requires production of the correct number and types of cells during development; cascades of transcription factors are essential for cellular coordination. Sox proteins are transcription factors that affect various processes in the development of the nervous system. Sox11, a member of the SoxC family, is expressed in differentiated neurons and supports neuronal differentiation in several systems. To understand how generalizable the actions of Sox11 are across phylogeny, its function in the development of the frog nervous system and the mouse cerebral cortex were compared. Expression of Sox11 is largely conserved between these species; in the developing frog, Sox11 is expressed in the neural plate, neural tube and throughout the segmented brain, while in the mouse cerebral cortex, Sox11 is expressed in differentiated zones, including the preplate, subplate, marginal zone and cortical plate. In both frog and mouse, data demonstrate that Sox11 supports a role in promoting neuronal differentiation, with Sox11-positive cells expressing pan-neural markers and becoming morphologically complex. However, frog and mouse Sox11 cannot substitute for one another; a functional difference likely reflected in sequence divergence. Thus, Sox11 appears to act similarly in subserving neuronal differentiation but is species-specific in frog neural development and mouse corticogenesis. Summary: Sox11 acts to designate neurons in both mouse and frog brains, but orthologs are not functionally redundant. These data show evolutionary conservation of Sox11 function with molecular divergence. |
| Databáze: | OpenAIRE |
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