Histologic response after neoadjuvant chemoradiotherapy in locally advanced rectal adenocarcinoma: experience from Sudan
| Autor: | Hussein Abdalla M. Ali, Ahmed Abd Elrahman Abdalla, Awad Ali M. Alawad |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer medicine.medical_treatment 030231 tropical medicine Adenocarcinoma Metastasis Sudan 03 medical and health sciences 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols Outcome Assessment Health Care medicine Rectal Adenocarcinoma Humans Stage (cooking) Neoadjuvant therapy Neoplasm Staging business.industry Rectal Neoplasms Cancer General Medicine Chemoradiotherapy Articles medicine.disease Total mesorectal excision Neoadjuvant Therapy Neoadjuvant rectal cancer chemoradiation pathological response Surgery Histopathology Female business |
| Zdroj: | African Health Sciences; Vol 16, No 3 (2016); 750-754 |
| ISSN: | 1729-0503 1680-6905 |
| Popis: | Background : Locally advanced rectal cancer can be down staged by neoadjuvant therapy and the resultant tumor response can be quantified histologically. This study aimed to assess pathological response of neoadjuvant chemoradiation in patients with locally advanced rectal cancers treated in Wad Medani Teaching Hospital (WMTH) and National Cancer Institute (NCI), Wad Medani, Sudan. Patients and methods : A total of 36 consecutive patients with locally advanced rectal cancer that were managed in WMTH and NCI during the period from 2006-2011 were reviewed. Preoperative pelvic radiotherapy was delivered. Total of 46 Gray were delivered concurrently with 5- fluorouracil (5-FU) on the first and last week of radiation. Total mesorectal excision of the rectal tumour either by anterior or abdominoperineal resections was planned at 6-8 weeks from completion of preoperative treatment. The pathological response to therapy was assessed by histopathology examination of the surgical specimen. Results : Initial clinical staging of patients revealed 58.3% of them were stage T3/T4N2M0 and 41.7% were stage T3N0M0. Down-staging to stage T1/T2N0M0 was found in 36.1% and stage T3N0M0 in 30.6%. No response was seen in 8.3% of cases with stage T3/T4N2M0 while complete clinical response (no residual) was seen in 25.0%. Complete histological response was observed in 13.8%. Positive lymph-nodes metastasis was confirmed in 8.3% of cases. Conclusion : Neoadjuvant chemoradiation is a reasonable option for cases of rectal cancer and deserves further evaluation. Keywords : Neoadjuvant, rectal cancer, chemoradiation, pathological response. |
| Databáze: | OpenAIRE |
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