Daphnane- and tigliane-type diterpenoid esters and orthoesters from Pimelea elongata
| Autor: | Patricia Y. Hayes, James J. De Voss, Mary T. Fletcher, Michael J. Somerville, Sharon Chow |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pharmacology
biology Molecular Structure Chemistry Stereochemistry Organic Chemistry Pharmaceutical Science Esters Stereoisomerism biology.organism_classification Terpenoid Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine Thymelaeaceae Drug Discovery Molecular Medicine Orthoester Diterpene Diterpenes Pimelea Nuclear Magnetic Resonance Biomolecular |
| Zdroj: | Journal of natural products. 73(11) |
| ISSN: | 1520-6025 |
| Popis: | Investigation of Pimelea elongata ("Lakebed Pimelea") afforded 18 tigliane- and daphnane-type diterpenes (1-18). Eight of these were new compounds: four (1-3, 5) tigliane esters and four (7, 8, 10, 11) daphnane orthoesters. The 10 known compounds were 12-O-decanoylphorbol-13-acetate (4), P. simplex subtoxin B (6), wikstroelide E (9), pimelotides A and B (12, 13), gnidiglaucin (14), simplexin (15), huratoxin (16), kirkinine D (17), and 12-beta-acetoxyhuratoxin (18). The structures and relative configurations of the new compounds were determined by ID and 2D NMR spectroscopic studies in combination with MS analyses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|