Presenilins – in search of functionality
| Autor: | Carol W. Gray, Gary Christie, David Allsop, John B. Davis, Eric Karran, Robin V. Ward, F. Mansfield |
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| Rok vydání: | 1998 |
| Předmět: |
Models
Molecular Protein Conformation Molecular Sequence Data Mutant Cleavage (embryo) Bioinformatics Biochemistry Presenilin Cell membrane Mice Protein structure Alzheimer Disease Presenilin-2 Presenilin-1 medicine Animals Humans Point Mutation Amino Acid Sequence Mice Knockout Neurons Chemistry Cell Membrane Membrane Proteins Cell biology medicine.anatomical_structure Membrane protein Knockout mouse Signal transduction Signal Transduction |
| Zdroj: | Biochemical Society Transactions. 26:491-496 |
| ISSN: | 1470-8752 0300-5127 |
| Popis: | The discovery of the PS proteins, the complexities of their biochemistry and their potential involvement in signalling pathways and in apoptosis have galvanized research into AD. To date, the aspect of the functionality of the PSs most relevant to the pathology of AD is the effect of PS FAD mutants to increase the proportion of A beta 42 produced from cells. This, coupled to the observation that gamma-secretase cleavage is considerably reduced in neurons derived from PS-1 knockout mice, argues strongly that PS plays a very direct role in the proteolytic processing of APP. |
| Databáze: | OpenAIRE |
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