Estimation of the width of free margin with a significant impact on local recurrence in surgical resection of oral squamous cell carcinoma
| Autor: | Tetsu Shimane, Takahiro Kamata, Hirokazu Tanaka, Shinobu Uehara, T. Yamamoto, Hiroshi Kurita, Shin-ichi Yamada |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Surgical resection Surgical margin medicine.medical_specialty Oncological surgery Close margin 03 medical and health sciences 0302 clinical medicine Risk Factors Margin (machine learning) Statistical significance medicine Humans Basal cell 030223 otorhinolaryngology Aged Retrospective Studies Aged 80 and over business.industry Middle Aged Prognosis Surgery Otorhinolaryngology Chemotherapy Adjuvant Lymphatic Metastasis 030220 oncology & carcinogenesis Carcinoma Squamous Cell Resection margin Female Mouth Neoplasms Radiotherapy Adjuvant Neoplasm Recurrence Local Oral Surgery business |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 45:147-152 |
| ISSN: | 0901-5027 |
| DOI: | 10.1016/j.ijom.2015.09.024 |
| Popis: | The purpose of this study was to estimate the width of free margin with a significant impact on local recurrence in surgical resection of oral squamous cell carcinoma (OSCC). Clinical and pathological data of 127 consecutive patients who underwent radical resection of OSCC were analyzed retrospectively. The local control rate was compared between patients with clear, close, and involved surgical margins, changing the required width of free margin for the definition of 'close surgical margin' (from 1 to 5mm). If a free margin of within 1, 2, or 4mm was judged a close margin, the risk of local recurrence was significantly different among the patients with clear, close, and involved surgical margins. If the definition of close margin was within 5mm of the resection margin, the difference between clear and close margin did not reach statistical significance. The results of this study suggest that 5mm of clearance at the surgical resection margin should be the index of oncological surgery. More than 5mm of histological free margin around OSCC is not justified in terms of the risk management of local recurrence and the resultant morbidity. |
| Databáze: | OpenAIRE |
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