Outcomes of open partial nephrectomy for renal cell carcinoma in the minimally invasive approach era
| Autor: | Tetsuya Shindo, Hidetoshi Tabata, Kohei Hashimoto, Kosuke Shibamori, Yuki Kyoda, Ko Kobayashi, Naoya Masumori, Toshiaki Tanaka |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Minimally invasive approach business.industry Urology medicine.disease Diseases of the genitourinary system. Urology Renal cell carcinoma Editor Recommendations Open partial nephrectomy Oncology Reproductive Medicine Ischemic time Medicine RC870-923 business Renal function |
| Zdroj: | Current Urology Current Urology, Vol 15, Iss 4, Pp 198-203 (2021) |
| ISSN: | 1661-7657 1661-7649 |
| Popis: | Background:. We investigated the characteristics and outcomes of patients who underwent open partial nephrectomy (OPN) in the minimally invasive approach era. Materials and methods:. We retrospectively reviewed 52 patients (55 cases) who underwent OPN from May 2009 to March 2016. We assessed perioperative change in estimated glomerular filtration rate (eGFR), complications, and oncological outcomes. Tumor complexity was evaluated using the R.E.N.A.L nephrometry score (NS) and the modified NS. Results:. Fifteen cases (27%) had imperative indications and 40 (73%) had elective indications. The elective cases were more likely to have adverse tumor complexity based on NS. The perioperative complication rate defined as a Clavien-Dindo grade ≥IIIa was 11%. The rate of postoperative decline in eGFR at 1 month, 1 year, and 2 years was 22%, 20%, and 21%, respectively. Multivariate analysis revealed that male gender (odds ratio [OR] 11.8, p = 0.03), NS ≥9 (OR 13.9, p = 0.02), modified NS ≥11 (OR 13.5, p = 0.01), and cold ischemic time ≥40 minutes (OR 7.9, p = 0.04) were significantly associated with worsening eGFR at 1 year after surgery. During a median follow-up period of 52 months, the 5-year overall survival and recurrence-free survival rates were 93% and 84%, respectively. Conclusions:. OPN is acceptable with regard to oncological outcomes and complications in the minimally invasive surgery era. We propose that OPN should be the preferred approach in cases in which it is technically difficult to preserve maximum renal function via a minimally invasive approach. |
| Databáze: | OpenAIRE |
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