Clotrimazole inhibits cell proliferation in vitro and in vivo
| Autor: | Laura R. Benzaquen, H R Byers, Jose A. Halperin, Carlo Brugnara, S Gatton-Celli |
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| Rok vydání: | 1995 |
| Předmět: |
Intracellular Fluid
Male Lung Neoplasms Antineoplastic Agents Mice SCID Pharmacology Biology General Biochemistry Genetics and Molecular Biology Cell Line Mice In vivo Tumor Cells Cultured medicine Animals Humans Clotrimazole Melanoma Cellular compartment Cell growth 3T3 Cells General Medicine Calcium Channel Blockers Molecular biology Growth Inhibitors In vitro Cell Compartmentation Rats Cytosol Cell culture Neoplastic Stem Cells Calcium Cattle Female Endothelium Vascular Cell Division Neoplasm Transplantation Intracellular medicine.drug |
| Zdroj: | Nature Medicine. 1:534-540 |
| ISSN: | 1546-170X 1078-8956 |
| Popis: | Cell proliferation is critically dependent on the regulated movement of ions across various cellular compartments. The antimycotic drug clotrimazole (CLT) has been shown to inhibit movement of Ca2+ and K+ across the plasma membrane. Our results show that CLT inhibits the rate of cell proliferation of normal and cancer cell lines in a reversible and dose-dependent manner in vitro. Moreover, CLT depletes the intracellular Ca2+ stores and prevents the rise in cytosolic Ca2+ that normally follows mitogenic stimulation. In mice with severe combined immunodeficiency disease (SCID) and inoculated intravenously with MM-RU human melanoma cells, daily subcutaneous injections of CLT induced a significant reduction in the number of lung metastases. Modulation of early ionic mitogenic signals and potent inhibition of cell proliferation both in vitro and in vivo are new and potentially useful clinical effects of CLT. |
| Databáze: | OpenAIRE |
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