Healthy lifestyle and the risk of pancreatic cancer in the EPIC study

Autor: Paul Brennan, Salvatore Panico, Rosario Tumino, Isabel Drake, Kristin Benjaminsen Borch, Giovana Masala, Christina C. Dahm, Manuela M. Bergmann, Kim Overvad, Elisabete Weiderpass, Rudolf Kaaks, María José Sánchez, Sara Regnér, Anja Olsen, Elio Riboli, H. Bas Bueno-de-Mesquita, María Dolores López, Carlotta Sacerdote, Vinciane Rebours, Francesca Mancini, Marc J. Gunter, Eva Ardanaz, Antonia Trichopoulou, Vivian Viallon, Eric J. Duell, Anne M. May, Ruth C. Travis, Flavie Perrier, Anne Tjønneland, Heinz Freisling, José Ramón Quirós, Pilar Amiano Exezarreta, Verena Katzke, Valeria Pala, Eleni Peppa, Anna Karakatsani, Dagfinn Aune, Carla H. van Gils, Mazda Jenab, Fiona McKenzie, Heiner Boeing, Marie-Christine Boutron-Ruault, Sabine Naudin, Malin Sund, Dana Hashim, Nicholas J. Wareham, Charlotta Rylander, Pietro Ferrari
Přispěvatelé: Naudin, Sabine [0000-0003-1049-6225], Apollo - University of Cambridge Repository
Rok vydání: 2019
Předmět:
Male
Epidemiology
030204 cardiovascular system & hematology
EPIC
Cohort Studies
0302 clinical medicine
Risk Factors
Medicine
Prospective Studies
030212 general & internal medicine
Prospective cohort study
Pancreas cancer
Incidence
Incidence (epidemiology)
Smoking
Obesity
Abdominal
Female
Epic study
Cohort study
Estils de vida
medicine.medical_specialty
Alcohol Drinking
Lifestyles
Nutritional Status
Estil de vida
Article
1117 Public Health and Health Services
03 medical and health sciences
Population attributable fraction
Pancreatic cancer
Humans
Healthy Lifestyle
Obesity
Prospective study
Nutrició
Exercise
Càncer de pàncrees
Nutrition
Proportional Hazards Models
Waist-Hip Ratio
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762
business.industry
Healthy Lifestyle Index
Public health
Lifestyle
medicine.disease
Pancreatic Neoplasms
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762
Family medicine
business
Zdroj: Naudin, S, Viallon, V, Hashim, D, Freisling, H, Jenab, M, Weiderpass, E, Perrier, F, McKenzie, F, Bueno-de-Mesquita, H B, Olsen, A, Tjønneland, A, Dahm, C C, Overvad, K, Mancini, F R, Rebours, V, Boutron-Ruault, M-C, Katzke, V, Kaaks, R, Bergmann, M, Boeing, H, Peppa, E, Karakatsani, A, Trichopoulou, A, Pala, V, Masala, G, Panico, S, Tumino, R, Sacerdote, C, May, A M, van Gils, C H, Rylander, C, Borch, K B, Chirlaque López, M D, Sánchez, M-J, Ardanaz, E, Quirós, J R, Amiano Exezarreta, P, Sund, M, Drake, I, Regnér, S, Travis, R C, Wareham, N, Aune, D, Riboli, E, Gunter, M J, Duell, E J, Brennan, P & Ferrari, P 2020, ' Healthy lifestyle and the risk of pancreatic cancer in the EPIC study ', European Journal of Epidemiology, vol. 35, pp. 975–986 . https://doi.org/10.1007/s10654-019-00559-6
Dipòsit Digital de la UB
Universidad de Barcelona
Naudin, S, Viallon, V, Hashim, D, Freisling, H, Jenab, M, Weiderpass, E, Perrier, F, McKenzie, F, Bueno-de-Mesquita, H B, Olsen, A, Tjønneland, A, Dahm, C C, Overvad, K, Mancini, F R, Rebours, V, Boutron-Ruault, M C, Katzke, V, Kaaks, R, Bergmann, M, Boeing, H, Peppa, E, Karakatsani, A, Trichopoulou, A, Pala, V, Masala, G, Panico, S, Tumino, R, Sacerdote, C, May, A M, van Gils, C H, Rylander, C, Borch, K B, Chirlaque López, M D, Sánchez, M J, Ardanaz, E, Quirós, J R, Amiano Exezarreta, P, Sund, M, Drake, I, Regnér, S, Travis, R C, Wareham, N, Aune, D, Riboli, E, Gunter, M J, Duell, E J, Brennan, P & Ferrari, P 2020, ' Healthy lifestyle and the risk of pancreatic cancer in the EPIC study ', European Journal of Epidemiology, vol. 35, pp. 975–986 . https://doi.org/10.1007/s10654-019-00559-6
Eur J Epidemiol
Naudin, S, Viallon, V, Hashim, D, Freisling, H, Jenab, M, Weiderpass, E, Perrier, F, McKenzie, F, Bueno-de-Mesquita, H B, Olsen, A, Tjønneland, A, Dahm, C C, Overvad, K, Mancini, F R, Rebours, V, Boutron-Ruault, M-C, Katzke, V, Kaaks, R, Bergmann, M, Boeing, H, Peppa, E, Karakatsani, A, Trichopoulou, A, Pala, V, Masala, G, Panico, S, Tumino, R, Sacerdote, C, May, A M, van Gils, C H, Rylander, C, Borch, K B, Chirlaque López, M D, Sánchez, M-J, Ardanaz, E, Quirós, J R, Amiano Exezarreta, P, Sund, M, Drake, I, Regnér, S, Travis, R C, Wareham, N, Aune, D, Riboli, E, Gunter, M J, Duell, E J, Brennan, P & Ferrari, P 2020, ' Healthy lifestyle and the risk of pancreatic cancer in the EPIC study ', European Journal of Epidemiology, vol. 35, no. 10, 35 . https://doi.org/10.1007/s10654-019-00559-6
ISSN: 1573-7284
0393-2990
DOI: 10.1007/s10654-019-00559-6
Popis: This is a post-peer-review, pre-copyedit version of an article published in the European Journal of Epidemiology. The final authenticated version is available online at: https://doi.org/10.1007/s10654-019-00559-6. Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants’ shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e−09) and 0.77 (0.72, 0.82; ptrend = 1.7e−15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e−04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.
Databáze: OpenAIRE
Externí odkaz: