The association of vascular endothelial growth factor related SNPs and circulating iron levels might depend on body mass index
| Autor: | Said El Shamieh, Sophie Visvikis-Siest, Mariam Ibrahim, Ali Salami, Pia Chedid |
|---|---|
| Přispěvatelé: | Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), University of Balamand [Liban] (UOB), Lebanese University [Beirut] (LU), Beirut Arab University [Beyrouth, Liban] (BAU), SIEST, Sofia |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Vascular Endothelial Growth Factor A
General Immunology and Microbiology Genotype Vascular Endothelial Growth Factors Iron [SDV]Life Sciences [q-bio] Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology [SDV] Life Sciences [q-bio] Iron levels Humans Vascular endothelial growth factor Body mass index SNPs |
| Zdroj: | Frontiers in Bioscience-Landmark Frontiers in Bioscience-Landmark, IMR Press, 2022, 27 (1), pp.1. ⟨10.31083/j.fbl2701027⟩ |
| ISSN: | 2768-6701 2768-6698 |
| Popis: | International audience; Background and objectives: Vascular Endothelial Growth Factor (VEGF) is an essential regulator of vascular biology. In addition to the well-established role in angiogenesis, circulating VEGF levels were found elevated in severely anemic patients, pointing out that anemia might affect the progression of angiogenesis in malignant and benign diseases through the alteration of VEGF levels. Ten single nucleotide polymorphisms (SNPs) in VEGFA and other loci were shown to explain more than 50% of its circulating levels. This study investigated the association of those ten VEGF-related SNPs with serum iron levels in a general Lebanese population free of chronic diseases (N = 460).Result: We found that the rs10738760 and the body mass index (BMI) were associated with decreased Iron levels (p = 0.002, and p < 0.001, respectively). When taken together, both variables, rs10738760 and BMI, interacted to reduce iron levels (p < 0.001). According to obesity status, the stratification revealed that the effect of rs10738760 was more pronounced in obese than non-obese individuals (p = 0.025). Conclusion: The intergenic SNP rs10738760 is associated with circulating iron levels, and this association depends on BMI status. Although of interest, these results need replication in larger populations from different ancestries. |
| Databáze: | OpenAIRE |
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