| Autor: |
Shiyu, Hao, Chunyan, Yang, Peng, Song, Hewen, Shi, Ying, Zou, Meiyang, Chen, Xingli, Wu, Yancun, Yin, Zhenhai, Yu, Weiwei, Zhu, Minjing, Li |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Biochemical and Biophysical Research Communications. 619:137-143 |
| ISSN: |
0006-291X |
| DOI: |
10.1016/j.bbrc.2022.06.031 |
| Popis: |
Acute myeloid leukemia (AML) is the most common acute leukemia affecting adults. The tight junction protein CLDN4 is closely related to the development of various epithelial cell carcinomas. However, whether CLDN4 contributes to AML development remains unclear. For the first time, we found that expression of CLDN4 is aberrantly up-regulated in AML cells. Knockdown of CLDN4 expression resulted in a dramatic decreased cell growth, elevated apoptosis of AML cells. Further, we revealed that knockdown of CLDN4 inhibits mRNA expression of PIK3R3 and MAP2K2, thus suppresses activation of AKT and ERK1/2. More importantly, activating AKT branch by SC79 partially compromised CLDN4 knockdown induced cell viability inhibition. In addition, we found that higher expression of CLDN4 is connected to worse survival and is an independent indicator of shorter disease free survival (DFS) in AML patients. Together, our results indicate that CLDN4 contributes to AML pathogenesis, and suggests that targeting CLDN4 is a promising option for AML treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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