Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 (FGF-21) as biomarkers of subclinical atherosclerosis in women
| Autor: | Alma Grisel Díaz Martínez, Laura Alejandra Mejía Alonso, Francisco Avelar, Leticia Manuel-Apolinar, Lourdes Basurto, Lucero Sánchez-Huerta, Rosalinda Sánchez-Arenas, Michael A. Gregory, Susana Barrera Hernández |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty FGF21 Infarction Disease Logistic regression Carotid Intima-Media Thickness Biochemistry Gastroenterology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine Genetics medicine Humans Obesity cardiovascular diseases Risk factor Mexico Molecular Biology Chemokine CCL2 Subclinical infection business.industry Cell Biology Middle Aged Atherosclerosis medicine.disease Fibroblast Growth Factors Postmenopause Carotid Arteries Cross-Sectional Studies Logistic Models 030104 developmental biology Female business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Experimental Gerontology. 124:110624 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2019.05.013 |
| Popis: | Background Atherosclerosis is a primary risk factor for cardiovascular disease (CVD). Proinflammatory biochemical factors can influence vascular health; monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with CVD while fibroblast growth factor-21 (FGF-21) acts directly on cardiac tissue to reduce infarction damage. However, the relationship between plasma concentrations of MCP-1, FGF-21 and subclinical CVD indices remains equivocal. Aim To determine the association between MCP-1, FGF-21 and subclinical atherosclerosis [i.e., carotid intima-media thickness (cIMT)] in women without clinical evidence of CVD. Methods: A cross-sectional analysis of 140 women without history of CVD was performed. Anthropometrics were collected, serum concentrations of MCP-1 and FGF-21 were determined by enzyme-linked immunosorbent assay, and cIMT was quantified (B-mode ultrasonography). The correlations between MCP-1, FGF-21 and the presence of clinical and laboratory of subclinical atherosclerosis (i.e., cIMT ≥0.70 mm), comparison intergroup and odd ratio with multiple logistic regression were analyzed. Results MCP-1, but not FGF-21 correlated with some obesity indicators. In median comparison among groups, subclinical atherosclerosis showed higher serum concentrations of MCP-1and lower serum concentrations of FGF-21. In postmenopausal women, there were significant differences MCP-1 (p = 0.001), and FGF-21 (p = 0.010). Multiple logistic regression analysis in postmenopausal women with subclinical atherosclerosis, between MCP-1 (p = 0.001) and FGF-21 (p = 0.037) showed association with cIMT, along with age. Conclusions MCP-1 and FGF-21 levels are associated with subclinical atherosclerosis disease severity (i.e., cIMT) in postmenopausal women without CVD. Further efforts focused on characterizing the relationship between novel blood-borne markers of early CVD pathology are warranted and should be pursued. |
| Databáze: | OpenAIRE |
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