Serum concentrations of sICAM‐1, sE‐, sP‐ and sL‐selectins in patients withSchistosoma mansoniinfection and association with disease severity
| Autor: | Philippe Esterre, C.E. Ramarokoto, Raobelison A, Pascal Boisier, V.E. Ravaoalimalala, Jean Roux |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Adolescent Immunology Intercellular Adhesion Molecule-1 Schistosomiasis Biology Severity of Illness Index Feces chemistry.chemical_compound Fibrosis parasitic diseases Severity of illness Hyaluronic acid medicine Animals Humans Longitudinal Studies Hyaluronic Acid Child Parasite Egg Count Ultrasonography Schistosoma mansoni Middle Aged medicine.disease biology.organism_classification Schistosomiasis mansoni Praziquantel chemistry Selectins Female Parasitology Biomarkers Selectin Follow-Up Studies medicine.drug |
| Zdroj: | Parasite Immunology. 20:369-376 |
| ISSN: | 1365-3024 0141-9838 |
| Popis: | Increased serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1, CD54) and of soluble E- (CD62E), but not soluble P- (CD62P) and L- (CD62 L) selectins, were detected in Malagasy patients living in an hyperendemic focus of Schistosoma mansoni. Levels of sICAM-1 remained elevated for several months after treatment with praziquantel. Serum levels of ICAM-1, but not of other markers, were significantly correlated with the disease severity, as indicated by ultrasonographical data, and with some circulating fibrosis markers (at least hyaluronic acid). sICAM-1 level may reflect endothelial inflammatory reactions, probably harmful, in the liver and may be useful for monitoring morbidity evolution in schistosomiasis mansoni. |
| Databáze: | OpenAIRE |
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