Multivalent, High-Relaxivity MRI Contrast Agents Using Rigid Cysteine-Reactive Gadolinium Complexes
| Autor: | Kenneth N. Raymond, Ankona Datta, Dante W. Romanini, Praveena D. Garimella, Matthew B. Francis |
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| Rok vydání: | 2011 |
| Předmět: |
Models
Molecular Contrast enhancement medicine.diagnostic_test Gadolinium Contrast Media chemistry.chemical_element Magnetic resonance imaging General Chemistry Magnetic Resonance Imaging Biochemistry Article Catalysis Capsid Colloid and Surface Chemistry Nuclear magnetic resonance chemistry Organometallic Compounds medicine Cysteine Surface protein Linker |
| Zdroj: | Journal of the American Chemical Society. 133:14704-14709 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja204516p |
| Popis: | MRI contrast agents providing very high relaxivity values can be obtained through the attachment of multiple gadolinium(III) complexes to the interior surfaces of genome-free viral capsids. In previous studies, the contrast enhancement was predicted to depend on the rigidity of the linker attaching the MRI agents to the protein surface. To test this hypothesis, a new set of Gd-hydroxypyridonate based MRI agents was prepared and attached to genetically introduced cysteine residues through flexible and rigid linkers. Greater contrast enhancements were seen for MRI agents that were attached via rigid linkers, validating the design concept and outlining a path for future improvements of nanoscale MRI contrast agents. |
| Databáze: | OpenAIRE |
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