Excipient Stability in Oral Solid Dosage Forms: A Review
| Autor: | Tarul D Mulay, Mittal Darji, Sushrut Marathe, Tasnim Fatima, Rahul Lalge, S. Narasimha Murthy, Michael A. Repka, Hyung Kyung Lee, Alia Alshammari |
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| Rok vydání: | 2017 |
| Předmět: |
Oxidative degradation
Drug Compounding Pharmacology toxicology Administration Oral Pharmaceutical Science Excipient Capsules 02 engineering and technology Aquatic Science Pharmaceutical formulation 030226 pharmacology & pharmacy Dosage form Excipients 03 medical and health sciences 0302 clinical medicine Drug Stability Drug Discovery medicine Ecology Evolution Behavior and Systematics Active ingredient Chromatography Ecology Chemistry General Medicine 021001 nanoscience & nanotechnology Biochemical engineering 0210 nano-technology Agronomy and Crop Science Tablets medicine.drug |
| Zdroj: | AAPS PharmSciTech. 19:12-26 |
| ISSN: | 1530-9932 |
| Popis: | The choice of excipients constitutes a major part of preformulation and formulation studies during the preparation of pharmaceutical dosage forms. The physical, mechanical, and chemical properties of excipients affect various formulation parameters, such as disintegration, dissolution, and shelf life, and significantly influence the final product. Therefore, several studies have been performed to evaluate the effect of drug-excipient interactions on the overall formulation. This article reviews the information available on the physical and chemical instabilities of excipients and their incompatibilities with the active pharmaceutical ingredient in solid oral dosage forms, during various drug-manufacturing processes. The impact of these interactions on the drug formulation process has been discussed in detail. Examples of various excipients used in solid oral dosage forms have been included to elaborate on different drug-excipient interactions. |
| Databáze: | OpenAIRE |
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