Health-related quality of life after colorectal cancer in England: a patient-reported outcomes study of individuals 12 to 36 months after diagnosis
Autor: | Amy Downing, Adam Glaser, Michael J Richards, David Sebag-Montefiore, Eva Morris, Charlotte Wood, Paul Kind, Paul J. Finan, Richard Wagland, Penny Wright, Sally W. Vernon, Richard G. Feltbower, Sarah Lawton, James D. Thomas, Jessica Corner |
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Rok vydání: | 2015 |
Předmět: |
Male
Cancer Research medicine.medical_specialty Disease status Colorectal cancer Population RC 254 Neoplasms. Tumors. Oncology (including Cancer) MEDLINE Cancer therapy Quality of life (healthcare) Surveys and Questionnaires Medicine Humans education Aged Health related quality of life Response rate (survey) Aged 80 and over education.field_of_study business.industry Age Factors Middle Aged medicine.disease Oncology England Family medicine Physical therapy Quality of Life Female Self Report business Colorectal Neoplasms |
Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 33(6) |
ISSN: | 1527-7755 0732-183X |
Popis: | Purpose This population-level study was conducted to define the health-related quality of life (HRQL) of individuals living with and beyond colorectal cancer (CRC) and to identify factors associated with poor health outcomes. Patients and Methods All individuals diagnosed with CRC in England in 2010 and 2011 who were alive 12 to 36 months after diagnosis were sent a questionnaire. This included questions related to treatment, disease status, other long-term conditions (LTCs), generic HRQL (EuroQol-5D), and cancer-specific outcomes (Functional Assessment of Cancer Therapy and Social Difficulties Inventory items). Results The response rate was 63.3% (21,802 of 34,467 patients). One or more generic health problems were reported by 65% of respondents, with 10% of patients reporting problems in all five domains. The reporting of problems was higher than in the general population and was most marked in those age less than 55 years. Certain subgroups reported a higher number of problems, notably those with one or more other LTCs, those with active or recurrent disease, those with a stoma, and those at the extremes of the age range (< 55 and > 85 years). Of respondents without a stoma, 16.3% reported no bowel control. Reversal of a stoma resulted in fewer severe bowel problems but more moderate problems than those who had never had a stoma. A quarter of rectal cancer respondents (25.1%) reported difficulties with sexual matters (compared with 11.2% of colon cancer respondents). Conclusion This study demonstrates the success of a national patient-reported outcomes survey. The results have the potential to support system-wide improvement in health outcomes through the identification of particular challenges faced by individuals after treatment for CRC. |
Databáze: | OpenAIRE |
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