Platelet activation in nocturnal asthma
| Autor: | I. R. Craig, H. G. Dean, J. F. J. Morrison, S. B. Pearson, P. N. Bramley |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Atropine Male Pulmonary and Respiratory Medicine medicine.medical_specialty Peak Expiratory Flow Rate Platelet Factor 4 chemistry.chemical_compound Catecholamines Internal medicine Muscarinic acetylcholine receptor medicine Humans Platelet activation Asthma Platelet-activating factor business.industry Middle Aged Platelet Activation beta-Thromboglobulin medicine.disease Circadian Rhythm Endocrinology chemistry Beta-thromboglobulin Bronchial hyperresponsiveness Female business Platelet factor 4 Research Article medicine.drug |
| Zdroj: | Thorax. 46:197-200 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thx.46.3.197 |
| Popis: | Platelet activation may be a factor in the bronchial hyperresponsiveness that characterises asthma. As hyperresponsiveness is increased at night, changes in platelet activation over 24 hours were related to the diurnal changes in peak expiratory flow and plasma catecholamine concentrations in five subjects with asthma and five normal subjects. The effect of muscarinic receptor blockade with intravenous atropine at 0400 hours on these measurements was also studied. Platelet activation, assessed as the ration of beta thromboglobulin to platelet factor 4, was highest when the peak expiratory flow rate was at its lowest in the asthmatic subjects. There was no correlation between platelet activation and plasma catecholamine concentrations. Intravenous atropine did not alter the ratio of beta thromboglobulin to platelet factor 4, suggesting that parasympathetic activity is not the cause of the increased platelet activation at night. |
| Databáze: | OpenAIRE |
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