[Myeloproliferative disorders 'Philadelphia negative' and JAK2V617F mutation: study of 15 cases in Togo]
| Autor: | Irénée Messanh Delagnon Kueviakoe, Ahoefa Vovor, A. Y. Segbena, Kossi Agbetiafa, Ibrahima Sanogo, Koffi Amegbor, Stéphane Giraudier, Essohana Padaro, Yao Layibo |
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| Jazyk: | francouzština |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Phenylalanine Mutation Missense Essential Thrombocytemia Cohort Studies Myeloproliferative Disorders Polycythemia vera medicine Humans Philadelphia Chromosome Jak2v617f mutation Longitudinal Studies Myelofibrosis Aged Philadelphia negative business.industry Valine General Medicine Janus Kinase 2 Middle Aged medicine.disease Prognosis Middle age Amino Acid Substitution Togo Female business Cohort study |
| Zdroj: | Annales de biologie clinique. 70(5) |
| ISSN: | 1950-6112 |
| Popis: | The goal of our study is to document the prevalence of change JAK2V617F among patients reached of myeloproliferative syndromes (MPS) in Togo in order to evaluate frequencies. This descriptive study included 15 patients followed with the CHU Campus for a SMP. The research of JAK2 change by PCR was carried out with the APHP Henri Mondor of Creteil (France). During the study period, 15 patients followed for MPS (9 cases of polycythemia Vera, 5 cases of essential thrombocytemia and a case of primitive myelofibrosis) profited from the research of JAK2 change. The Middle age of the patients was respectively of 45±18 years; of 55±6 years for the PV and the essential thrombocytemia. The patient followed for primitive myelofibrosis was 72 years old. Sex-ratio (H/F) was of 2. JAK2 Change was positive in 5 cases out of 9 (55.5%) of the polycythemia Vera, at 3 patients out of 5 (60%) followed for essential thrombocytemia but negative for patient reached of primitive myelofibrosis. In conclusion, JAK2 Change has an interest diagnosis and forecast in the MPS negative Chromosom Philadelphia and can be systematic even in Africa Sub-saharian. |
| Databáze: | OpenAIRE |
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