The effect of a natural polyphenol supplement on iron absorption in adults with hereditary hemochromatosis
| Autor: | Buerkli, Simone, Salvioni, Laura, Koller, Natalie, Zeder, Christophe, Teles, Maria José, Porto, Graça, Habermann, Jana Helena, Dubach, Irina Léa, Vallelian, Florence, Frey, Beat M, Moretti, Diego, Baumgartner, Jeannine, Zimmermann, Michael B |
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| Přispěvatelé: | University of Zurich, Buerkli, Simone |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Cross-Over Studies Nutrition and Dietetics Tea Iron Histocompatibility Antigens Class I Polyphenols Medicine (miscellaneous) 610 Medicine & health 2701 Medicine (miscellaneous) 2916 Nutrition and Dietetics Humans Single-Blind Method Hemochromatosis 10029 Clinic and Policlinic for Internal Medicine Powders Hemochromatosis Protein Iron Dietary |
| DOI: | 10.5167/uzh-218532 |
| Popis: | Objectives We developed a natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH). Methods We performed in vitro iron digestion experiments to determine iron precipitation by 12 polyphenol-rich dietary sources, and formulated a polyphenol supplement (PPS) containing black tea powder, cocoa powder and grape juice extract. In a multi-center, single-blind, placebo-controlled cross-over study, we assessed the effect of the PPS on iron absorption from an extrinsically labelled test meal and test drink in patients (n = 14) with HH homozygous for the p.C282Y variant in the HFE gene. We measured fractional iron absorption (FIA) as stable iron isotope incorporation into erythrocytes. Results Black tea powder, cocoa powder and grape juice extract most effectively precipitated iron in vitro. A PPS mixture of these three extracts precipitated ~ 80% of iron when 2 g was added to a 500 g iron solution containing 20 µg Fe/g. In the iron absorption study, the PPS reduced FIA by ~ 40%: FIA from the meal consumed with the PPS was lower (3.01% (1.60, 5.64)) than with placebo (5.21% (3.92, 6.92)) (p = 0.026)), and FIA from the test drink with the PPS was lower (10.3% (7.29 14.6)) than with placebo (16.9% (12.8 22.2)) (p = 0.002). Conclusion Our results indicate that when taken with meals, this natural PPS can decrease dietary iron absorption, and might thereby reduce body iron accumulation and the frequency of phlebotomy in patients with HH. Trial registry: clinicaltrials.gov (registration date: 9.6.2019, NCT03990181). |
| Databáze: | OpenAIRE |
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