Human Norovirus: Experimental Models of Infection
| Autor: | Ralph A. Tripp, Kyle V. Todd |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
human norovirus 030106 microbiology lcsh:QR1-502 Review medicine.disease_cause lcsh:Microbiology 03 medical and health sciences Mice Virology Medicine Animals Humans Caliciviridae Infections Clinical Trials as Topic business.industry Norovirus Genetic systems Viral Vaccines Acute gastroenteritis animal models Reverse Genetics Gastroenteritis Disease Models Animal 030104 developmental biology Infectious Diseases vaccine development business |
| Zdroj: | Viruses Viruses, Vol 11, Iss 2, p 151 (2019) |
| ISSN: | 1999-4915 |
| Popis: | Human noroviruses (HuNoVs) are a leading cause of acute gastroenteritis worldwide. HuNoV infections lead to substantial societal and economic burdens. There are currently no licensed vaccines or therapeutics for the prevention or treatment of HuNoVs. A lack of well-characterized in vitro and in vivo infection models has limited the development of HuNoV countermeasures. Experimental infection of human volunteers and the use of related viruses such as murine NoV have provided helpful insights into HuNoV biology and vaccine and therapeutic development. There remains a need for robust animal models and reverse genetic systems to further HuNoV research. This review summarizes available HuNoV animal models and reverse genetic systems, while providing insight into their usefulness for vaccine and therapeutic development. |
| Databáze: | OpenAIRE |
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