Band 1p36 Abnormalities and t(1;17) in Ovarian Carcinoma
| Autor: | Jeffrey M. Trent, Mark A. Nelson, David S. Alberts, Raymond Taetle, Katherine M. Scott, Yun Liu, Julia Emerson, FH Thompson, Kathy Massey-Brown, Ronald S. Weinstein |
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| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
medicine.medical_specialty Chromosome Disorders Chromosomal translocation Adenocarcinoma DNA Satellite Biology Translocation Genetic Ovarian carcinoma Centromere Genetics medicine Humans Molecular Biology In Situ Hybridization Fluorescence Chromosome Aberrations Ovarian Neoplasms Breakpoint Cytogenetics Chromosome Mapping Chromosome medicine.disease Molecular biology Chromosome 17 (human) Chromosomes Human Pair 1 Female Chromosomes Human Pair 17 |
| Zdroj: | Cancer Genetics and Cytogenetics. 96:106-110 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(96)00307-x |
| Popis: | In a series of 128 karyotyped ovarian carcinomas, 42% of cases with chromosome 1 clonal structural abnormalities had breaks at band 1p36 (usually involving translocations of unknown material). Fluorescent in situ hybridization (FISH) studies using combinations of 1 centromere and 1p36.3-specific probes (16 cases) or 1 centromeric and 17 whole-chromosome paint probes (11 cases with 1p+) revealed a trend toward deletion of 1pter relative to 1 centromere (63%); intratumor heterogeneity; and the origin of 1p+ in 3/11 cases (27%) from chromosome 17 [t(1;17)(p36;?)]. The frequency of this specific breakpoint and its involvement in recurrent translocations suggest that these regions are loci for genes important in the pathogenesis of a subset of sporadic ovarian carcinomas. |
| Databáze: | OpenAIRE |
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