Visualization of Micro-Neuromas by Using In Vivo Confocal Microscopy: An Objective Biomarker for the Diagnosis of Neuropathic Corneal Pain?
| Autor: | Arsia Jamali, Andrea Cruzat, Anam Akhlaq, Alessandro Abbouda, Bernardo M. Cavalcanti, Pedram Hamrah, Hamid-Reza Moein, Gabriela Dieckmann, Zeina Salem, Rodrigo T Muller, Nicholas Pondelis |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Corneal nerve In vivo confocal microscopy Eye pain Pain Signs and symptoms Article Cornea 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Humans Retrospective Studies Microscopy Confocal business.industry Middle Aged 030104 developmental biology Clinical diagnosis Case-Control Studies 030221 ophthalmology & optometry Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Ocul Surf |
| Popis: | PURPOSE: The diagnosis of neuropathic corneal pain (NCP) is challenging, as it is often difficult to differentiate from conventional dry eye disease (DED). In addition to eye pain, NCP can present with similar signs and symptoms of DED. The purpose of this study is to find an objective diagnostic sign to identify patients with NCP, using in vivo confocal microscopy (IVCM). METHODS: This was a comparative, retrospective, case-control study. Patients with clinical diagnosis of NCP (n=25), DED (n=30), and age and sex-matched healthy controls (n=16), who underwent corneal imaging with IVCM (HRT3/RCM) were included. Central corneal IVCM scans were analyzed by 2 masked observers for nerve density and number, presence of micro-neuromas (terminal enlargements of subbasal corneal nerve) and/or nerve beading (bead-like formation along the nerves), and dendritiform cell (DC) density. RESULTS: There was a decrease in total nerve density in both NCP (14.14±1.03 mm/mm(2)) and DED patients (12.86±1.04 mm/mm(2)), as compared to normal controls (23.90±0.92 mm/mm(2); p |
| Databáze: | OpenAIRE |
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